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sporozoite

Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

November 10, 2009 - 20:48 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

 

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