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Genomics

Harnessing genomics and genome biology to understand malaria biology

April 19, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Sarah K. Volkman, Daniel E. Neafsey, Stephen F. Schaffner, Daniel J. Park & Dyann F. Wirth
Reference: 
Nature Reviews Genetics 13, 315-328 (May 2012)

MalariaWorldThis article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.

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Heritability of Antibody Isotype and Subclass Responses to Plasmodium falciparum Antigens

October 25, 2009 - 16:06 -- Bart G.J. Knols
Author(s): 
Tetteh KKA, Whittle HC, et al.
Reference: 
PLoS ONE 4(10): e7381. doi:10.1371/journal.pone.0007381

Genome-wide approaches are now warranted to map the major genetic determinants of variable antibody isotype and subclass responses to malaria, alongside evaluation of their impact on infection and disease. Although plasma levels of IgG4 to malaria antigens are generally low, the exceptionally high heritability of levels of this subclass in children deserves particular investigation.

 

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