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efficacy trial

Open Access | Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

March 23, 2010 - 21:10 -- Ingeborg van Schayk
Michael T White, Jamie T Griffin, Chris J Drakeley, Azra C Ghani
Malaria Journal 2010, 9:82 (23 March 2010)

Phase III trials of the malaria vaccine, RTS,S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy.

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