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demographic history

Letter: The demographic histories of the M and S molecular forms of Anopheles gambiae s.s.

March 21, 2010 - 10:41 -- Ingeborg van Schayk
Jacob E. Crawford and Brian P. Lazzaro
Mol. Biol. Evol. published 11 March 2010, 10.1093/molbev/msq070

Population genetic tests have been employed to detect natural selection at suspected An. gambiae anti-malaria genes, but these tests have generally been compromised by the lack of demographically correct null models. Here, we used a coalescent simulation approach within a maximum likelihood framework to fit population growth, bottleneck and migration models to polymorphism data from Cameroonian An. gambiae.

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