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antibodies

Open Access | Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection

October 22, 2010 - 08:48 -- Kabogo Ndegwa
Author(s): 
Ngoundou-Landji J, Nwuba RI, Anumudu CI, Odaibo AB, Matondo Maya WD, Awobode HO, Okafor CM, Morenikeji OA, Asinobi A, Nwagwu M, Holder AA, Ntoumi F
Reference: 
Malaria Journal 2010, 9:287 (18 October 2010)

In the search for correlates of protection against malaria, which will be essential to evaluate clinical trials of malaria vaccines based on MSP1, this study examines some potential assays and the factors that need to taken into account during their evaluation, using samples from individuals naturally exposed to malaria infection.

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Open Access |Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

February 26, 2010 - 17:15 -- Ingeborg van Schayk
Author(s): 
Kim J. M. Brolin, Kristina E. M. Persson, Mats Wahlgren, Stephen J. Rogerson, Qijun Chen
Reference: 
PLoS ONE 5(2): e9230

Understanding the characteristics of antibody response against VAR2CSA is undoubtedly imperative in order to design a functional and efficient vaccine against PAM.

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Naturally Acquired Antibodies to Plasmodium vivax Duffy Binding Protein (DBP) in Rural Brazilian Amazon

February 10, 2010 - 13:38 -- Ingeborg van Schayk
Author(s): 
Flávia A. Souza-Silva, Mônica da Silva-Nunes, Bruno A. M. Sanchez, Isabela P. Ceravolo, Rosely S. Malafronte, Cristiana F. A. Brito, Marcelo U. Ferreira, AND Luzia H. Carvalho
Reference: 
Am J Trop Med Hyg 2010;82 185-193

Duffy binding protein (DBP), a leading malaria vaccine candidate, plays a critical role in Plasmodium vivax erythrocyte invasion. Sixty-eight of 366 (18.6%) subjects had IgG anti-DBP antibodies by enzyme-linked immunosorbent assay (ELISA) in a community-based cross-sectional survey in the Brazilian Amazon Basin.

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Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals

October 29, 2009 - 12:12 -- Ingeborg van Schayk
Author(s): 
Thanh V Nguyen, John B Sacci Jr, Patricia de la Vega, Chandy C John, Anthony A James, Angray S Kang
Reference: 
Malaria Journal 2009, 8:235 (23 October 2009)

MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. A preliminary analysis of the human humoral response against MB2 indicates that it may be an additional highly conserved target for immune intervention at the pre-erythrocytic stage of P. falciparum life cycle.

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