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antibodies

Broadly reactive antibodies specific for Plasmodium falciparum MSP-119 are associated with the protection of naturally exposed children against infection

August 27, 2012 - 07:08 -- Kabogo Ndegwa
Author(s): 
Dent AE, Moormann AM, Yohn CT, Kimmel RJ, Sumba PO, Vulule J, Long CA, Narum DL, Crabb BS, Kazura JW, Tisch DJ
Reference: 
Malaria Journal 2012, 11:287 (21 August 2012)

MalariaWorldVariant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults.

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Open Access | Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso

March 29, 2012 - 08:32 -- Kabogo Ndegwa
Author(s): 
Diarra A, Nebie I, Tiono A, Soulama I, Ouedraogo A, Konate A, Theisen M, Dodoo D, Traore A, Sirima SB
Reference: 
Malaria Journal 2012, 11:79 (22 March 2012)

MalariaWorldAcquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.

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Pf332-C231-reactive antibodies affect growth and development of intra-erythrocytic Plasmodium falciparum parasites

December 1, 2011 - 13:38 -- Patrick Sampao
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Author(s): 
Halima A. Balogun, Nancy W. Awah, Salah E. Farouk, Klavs Berzins
Reference: 
Vaccine, Volume 30, Issue 1, 9 December 2011, Pages 21-28

MalariaWorldThe present study confirms the potential of Pf332 as a target antigen for parasite neutralizing antibodies, and further indicates that epitopes within the C231 region of Pf332 should constitute important tools in the dissection of the role of Pf332 in the biology of the malaria parasite, as well as in the design of a malaria vaccine.

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Mosquito ingestion of antibodies against mosquito midgut microbiota improves conversion of ookinetes to oocysts for Plasmodium falciparum, but not P. yoelii

November 25, 2011 - 15:01 -- Patrick Sampao
Author(s): 
Bruce H. Noden, Jefferson A. Vaughan, Charles B. Pumpuni, John C. Beier
Reference: 
Parasitology International, Volume 60, Issue 4, December 2011, Pages 440-446

MalariaWorldWhile this study highlights the complex interactions occurring between the parasite, mosquito, and midgut microbiota, the ultimate goal is to determine the influence of midgut microbiota on Plasmodium development in anopheline midguts in malaria endemic settings.

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Open Access | Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

June 22, 2011 - 07:00 -- Kabogo Ndegwa
Author(s): 
Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T. Riglar, Anthony N. Hodder, Stuart A. Ralph, Jake Baum, Alan F. Cowman
Reference: 
PLoS Pathog 7(6): e1002075

Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand-receptor interactions.

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Open Access | Human saliva as a source of anti-malarial antibodies to examine population exposure to Plasmodium falciparum

May 5, 2011 - 06:42 -- Kabogo Ndegwa
Author(s): 
Patricia Tabernero Estevez, Judith Satoguina, Davis C Nwakanma, Sheila West, David J Conway, Chris J Drakeley
Reference: 
Malaria Journal 2011, 10:104 (29 April 2011)

These data demonstrate anti- malarial antibodies can be detected in saliva and correlate strongly with levels in plasma.

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Open Access | Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins

February 15, 2011 - 09:18 -- Kabogo Ndegwa
Author(s): 
Avril M, Cartwright MM, Hathaway MJ, Smith JD
Reference: 
Malaria Journal 2011, 10:36 (11 February 2011)

Single domain VAR2CSA recombinant proteins produced in P. pastoris had limited efficacy in eliciting adhesion blocking antibody responses, but VAR2CSA DBL3 and DBL5 domains contain strain-transcendent epitopes that can be targeted by vaccination and may have application for vaccine development.

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Open Access | Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum

February 7, 2011 - 08:17 -- Kabogo Ndegwa
Author(s): 
Ashfaq Ghumra, Pongsak Khunrae, Ricardo Ataide, Ahmed Raza, Stephen J. Rogerson, Matthew K. Higgins, J. Alexandra Rowe
Reference: 
PLoS ONE 6(1): e16414

These results are encouraging for vaccine development as they show that potent antibodies can be generated to recombinant PfEMP1 domains that will inhibit rosetting and induce phagocytosis of infected erythrocytes.

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Antibodies to the Plasmodium falciparum rhoptry protein RAP-2/RSP-2 in relation to anaemia in Cameroonian children

January 18, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
N. Awah, H. Balogun, E. Achidi, L. A. Mariuba, P. A. Nogueria, P. Orlandi, M. Troye-Blomberg, J. Gysin, K. Berzins
Reference: 
Parasite Immunology, Volume 33, Issue 2, pages 104–115, February 2011

Previous studies have implicated reactive antibodies to the low molecular weight rhoptry-associated proteins (RAP-1, RAP-2/RSP-2 and RAP-3) in erythroid cell destruction during Plasmodium falciparum infection.

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High efficacy of anti DBL4var epsilon-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

December 28, 2010 - 12:40 -- Patrick Sampao
Author(s): 
Pamela A. Magistrado., Daniel Minja.,Morten A. Nielsen., et al.
Reference: 
Vaccine, Volume 29, Issue 3, 10 January 2011, Pages 437-443

In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4var epsilon recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania.

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