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anti-malaria drug trial

Opinion: The perils of PCR: can we accurately ‘correct’ antimalarial trials?

February 26, 2010 - 10:57 -- Kabogo Ndegwa
Author(s): 
Jonathan J. Juliano, Nahla Gadalla, Colin J. Sutherland, Steven R. Meshnick
Reference: 
Trends in Parasitology, Volume 26, Issue 3, March 2010, Pages 119-124

During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.

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