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pathogenesis

Not Open Access | T cell control of malaria pathogenesis

August 20, 2012 - 11:26 -- Patrick Sampao
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Author(s): 
Philip J Spence, Jean Langhorne
Reference: 
Current Opinion in Immunology, Volume 24, Issue 4, August 2012, Pages 444-448

MalariaWorldRecent evidence demonstrates that it is the interplay between CD4+ and CD8+ T cells, and the regulation of their response, throughout infection that dictates immunity and the pathogenesis of malaria.

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Not Open Access | Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis

August 20, 2012 - 11:15 -- Patrick Sampao
Author(s): 
Matthew L. Jones, Mark O. Collins, David Goulding, Jyoti S. Choudhary, Julian C. Rayner
Reference: 
Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 246-258

MalariaWorldUsing complementary palmitoyl protein purification approaches and quantitative mass spectrometry, we examined protein palmitoylation in asexual-stage P. falciparum parasites and identified over 400 palmitoylated proteins, including those involved in cytoadherence, drug resistance, signaling, development, and invasion.

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Cerebral malaria pathogenesis: revisiting parasite and host contributions

February 22, 2012 - 15:15 -- Patrick Sampao
Author(s): 
Grau, Georges Emile Raymond; Craig, Alister Gordon
Reference: 
Future Microbiology, Volume 7, Number 2, February 2012 , pp. 291-302(12)

MalariaWorldIn this article we examine the range of factors thought to influence the development of Plasmodium falciparum cerebral malaria in humans and review the evidence to support their role.

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The role of platelets in the pathogenesis of cerebral malaria

January 28, 2010 - 12:40 -- Kabogo Ndegwa
Author(s): 
Dermot Cox and Sam McConkey
Reference: 
Cellular and Molecular Life Sciences, Volume 67, Number 4 / February, 2010, Pages 557-568

There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria.

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