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phase 1 trial

Open Access | Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial

February 16, 2010 - 10:56 -- Ingeborg van Schayk
Author(s): 
Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, et al.
Reference: 
PLoS ONE 5(2): e9041

The FMP2.1/AS02A vaccine had a good safety profile, was well-tolerated, and induced high and sustained antibody levels in malaria-exposed children. This malaria vaccine is being evaluated in a Phase 2 efficacy trial in children at this site.

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Open Access | Phase 1 Trial of the Plasmodium falciparum Blood Stage Vaccine MSP142-C1/Alhydrogel with and without CPG 7909 in Malaria Naïve Adults

January 29, 2010 - 13:48 -- Ingeborg van Schayk
Author(s): 
Ellis RD, Martin LB, Shaffer D, Long CA, Miura K, et al.
Reference: 
PLoS ONE 5(1): e8787

A Phase 1 clinical trial was conducted in healthy malaria-naïve adults at the Center for Immunization Research in Washington, D.C., to evaluate the safety and immunogenicity of MSP142-C1/Alhydrogel +/− CPG 7909.

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