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gene expression

Open Access | Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

December 1, 2011 - 14:16 -- Patrick Sampao
Author(s): 
Lopez-Barragan MJ, Lemieux J, Quinones M, Williamson KC, Molina-Cruz A, Cui K, Barillas-Mury C, Zhao K, Su X
Reference: 
BMC Genomics 2011, 12:587 (30 November 2011)

MalariaWorldWe have sequenced seven bidirectional libraries from ring, early and late trophozoite, schizont, gametocyte II, gametocyte V, and ookinete, and four strand-specific libraries from late trophozoite, schizont, gametocyte II, and gametocyte V of the 3D7/NF4 parasites.

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Open Access | A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae.

June 8, 2011 - 14:26 -- Patrick Sampao
Author(s): 
Dean A Baker, Tony Nolan, Bettina Fischer, Alex Pinder, Andrea Crisanti and Steven Russell
Reference: 
BMC Genomics 2011, 12:296, 7 June 2011

In this study, we present transcription profiles for ~82% of annotated Anopheles genes in dissected adult male and female tissues.

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Open Access | Commentary: Dissecting gene expression in mosquito

June 8, 2011 - 14:18 -- Patrick Sampao
Author(s): 
Rayna Stamboliyska and John Parsch
Reference: 
BMC Genomics 2011, 12:297, 7 June 2011

In addition to providing a valuable resource for the community of mosquito researchers, the study allows comparative transcriptomic studies of dipteran insects to be extended over 250 million years of evolution, since the divergence of A. gambiae and Drosophila melanogaster

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Open Access | A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

May 5, 2011 - 08:04 -- Kabogo Ndegwa
Tags: 
Author(s): 
Shrawan Kumar Mishra, Prabhat Singh, Srikanta Kumar Rath
Reference: 
Malaria Journal 2011, 10:109 (2 May 2011)

These observations clearly indicate AQ+SP combination therapy is hepatotoxic in experimental Swiss mice.

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Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection

November 24, 2010 - 09:11 -- Patrick Sampao
Author(s): 
Denis Delic, Nicole Gailus, Hans-Werner Vohr, Mohamed Dkhil, Saleh Al-Quraishy and Frank Wunderlich
Reference: 
Journal of Molecular Endocrinology (2010) 45 379-390 

Here, we investigate as to whether this conversion coincides with permanent changes of hepatic gene expression profiles. Female mice aged 10–12 weeks were treated with testosterone for 3 weeks; then, testosterone treatment was discontinued for 12 weeks before challenging with 106 P. chabaudi-infected erythrocytes.

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Open access | Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum

January 19, 2010 - 19:40 -- Ingeborg van Schayk
Author(s): 
Brehelin L, Florent I, Gascuel O, Marechal E
Reference: 
BMC Genomics 2010, 11:35 (15 January 2010)

We propose a new method that uses gene expression data to assess inter-species annotation transfers.

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Open Access | An enhancer-like region regulates hrp3 promoter stage-specific gene expression in the human malaria parasite Plasmodium falciparum

December 8, 2009 - 12:39 -- Ingeborg van Schayk
Author(s): 
López-Estraño C, Gopalakrishnan AM, Semblat JP, Fergus MR, Mazier D, Haldar K.
Reference: 
Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):506-13

The data presented in this study demonstrates that stage specific promoter activity of the hrp3 gene in P. falciparum blood stage parasites is supported, at least in-part, by a small promoter region that can function in the absence of a larger chromosomal context.

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