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Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity

January 14, 2010 - 18:23 -- Kabogo Ndegwa
V. Tomar, G. Bhattacharjee, Kamaluddin, S. Rajakumar, Kumkum Srivastava, S.K. Puri
European Journal of Medicinal Chemistry, Volume 45, Issue 2, February 2010, Pages 745-751

A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3′-aminochalcone or 4′-aminochalcones and 9-chloroacridine.

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