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quinazoline derivatives

Original quinazoline derivatives displaying antiplasmodial properties

January 14, 2010 - 18:13 -- Kabogo Ndegwa
Author(s): 
Youssef Kabria, Nadine Azasb, Aurélien Dumètreb, Sébastien Hutterb, Michèle Lagetb, Pierre Verhaeghea, Armand Gellisa and Patrice Vanellea
Reference: 
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 616-622

The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).

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