The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10311 malaria professionals are enjoying the free benefits of MalariaWorld today

quinazoline derivatives

Original quinazoline derivatives displaying antiplasmodial properties

January 14, 2010 - 18:13 -- Kabogo Ndegwa
Youssef Kabria, Nadine Azasb, Aurélien Dumètreb, Sébastien Hutterb, Michèle Lagetb, Pierre Verhaeghea, Armand Gellisa and Patrice Vanellea
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 616-622

The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).

Subscribe to RSS - quinazoline derivatives