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antigen

Open Access | Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

January 10, 2010 - 15:11 -- Ingeborg van Schayk
Author(s): 
Alyssa E. Barry, Lee Schultz, Caroline O. Buckee, John C. Reeder
Reference: 
PLoS ONE 4(12): e8497

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design.

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Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

October 25, 2009 - 17:04 -- Bart G.J. Knols
Author(s): 
Shannon L. Takala et al.
Reference: 
Science Translational Medicine. 2009; 1:2ra5

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent the parasite from invading and replicating within host cells. No blood-stage malaria vaccine has shown clinical efficacy in humans. Most malaria vaccine antigens are parasite surface proteins that have evolved extensive genetic diversity, and this diversity could allow malaria parasites to escape vaccine-induced immunity. We examined the extent and within-host dynamics of genetic diversity in the blood-stage malaria vaccine antigen apical membrane antigen–1 in a longitudinal study in Mali. 

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