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polymorphism

Limited Polymorphism of the Plasmodium vivax Merozoite Surface Protein 1 Gene in Isolates from Turkey

December 3, 2010 - 07:35 -- Patrick Sampao
Author(s): 
Fadile Yildiz Zeyrek., Shin-Ichiro Tachibana., Kazuyuki Tanabe., et al.
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1230 - 1237.

Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.

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Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

October 25, 2009 - 17:04 -- Bart G.J. Knols
Author(s): 
Shannon L. Takala et al.
Reference: 
Science Translational Medicine. 2009; 1:2ra5

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent the parasite from invading and replicating within host cells. No blood-stage malaria vaccine has shown clinical efficacy in humans. Most malaria vaccine antigens are parasite surface proteins that have evolved extensive genetic diversity, and this diversity could allow malaria parasites to escape vaccine-induced immunity. We examined the extent and within-host dynamics of genetic diversity in the blood-stage malaria vaccine antigen apical membrane antigen–1 in a longitudinal study in Mali. 

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