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T-cell development

Changes in cell migration-related molecules expressed by thymic microenvironment during experimental Plasmodium berghei infection: consequences on thymocyte development

January 10, 2010 - 16:25 -- Ingeborg van Schayk
Author(s): 
Jacy Gameiro, Patrícia R. A. Nagib, Carolina F. Andrade, Déa M. S. Villa-Verde, Suse D. Silva-Barbosa, Wilson Savino, Fábio T. M. Costa, Liana Verinaud
Reference: 
Immunology, Volume 129 Issue 2, Pages 248 - 256

Overall, we show that the thymic atrophy observed in P. berghei-infected mice is accompanied by thymic microenvironmental changes that comprise altered expression of thymocyte migration-related molecules of the ECM and chemokine protein families, which in turn can alter the thymocyte migration pattern.

Medical Condition: 
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