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population genetics

Open Access | Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

January 10, 2010 - 15:11 -- Ingeborg van Schayk
Author(s): 
Alyssa E. Barry, Lee Schultz, Caroline O. Buckee, John C. Reeder
Reference: 
PLoS ONE 4(12): e8497

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design.

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