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GCE Special: Plasmodium falciparum infection in “humanised liver” mice

May 27, 2013 - 20:02 -- Bart G.J. Knols
Author(s): 
Jordana G. A. Coelho-dos-Reis, Xiangming Li, Eduardo L. V. Silveira, Rajakumar Mandraju, Soundarapandian Velmurugan, Sumana Chakravarty, Hiroshi Suemizu, Mamoru Ito, B. Kim Lee Sim, Stephen Hoffman, Moriya Tsuji
Reference: 
MWJ 2013, 4, 9

This GCE project aimed to establish “humanised liver” mice capable of supporting the full development of the liver stages of human malaria parasites. This could provide an invaluable opportunity to study various aspects of human malaria without the use of human volunteers. This would include investigating the biology of human malaria parasites in vivo and testing the potency of various agents against human malaria infection. Furthermore, “humanised liver” mice would give us the means by which efficient and economical precursor analysis can be done prior to the more expensive human clinical trials.

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Neither Mosquito Saliva nor Immunity to Saliva Has a Detectable Effect on the Infectivity of Plasmodium Sporozoites Injected into Mice

January 10, 2010 - 15:01 -- Ingeborg van Schayk
Author(s): 
Chahnaz Kebaier, Tatiana Voza, and Jerome Vanderberg
Reference: 
Infect. Immun. 2010;78 545-551

Prior studies had suggested that saliva may enhance sporozoite infectivity. Using rodent malaria models (Plasmodium berghei and P. yoelii), we were unable to show that saliva had any detectable effect on sporozoite infectivity.

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Short communication: Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria

December 16, 2009 - 10:44 -- Ingeborg van Schayk
Author(s): 
Jiraprapa Wipasa, Panida Hemsokana, Tunlaya Ruankham & Surat Hongsibsong
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 283-287

This study aimed to investigate the development of memory responses in susceptible A/J and resistant C57BL/6 mice which differ in the degree of susceptibility to clinical malaria following P. chabaudi AS infection.

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