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Open Access | Towards a precise test for malaria diagnosis in the Brazilian Amazon: comparison among field microscopy, a rapid diagnostic test, nested PCR, and a computational expert system based on artificial neural networks

May 7, 2010 - 07:00 -- Kabogo Ndegwa
Author(s): 
Andrade BB, Reis-Filho A, Barros AM, Souza-Neto SM, Nogueira LL, Fukutani KF, Camargo EP, Camargo LM, Barral A, Duarte A, Barral-Netto M
Reference: 
Malaria Journal 2010, 9:117 (6 May 2010)

An RDT for malaria diagnosis may find a promising use in the Brazilian Amazon integrating a rational diagnostic approach. Despite the low performance of the MalDANN test using solely epidemiological data, an approach based on neural networks may be feasible in cases where simpler methods for discriminating individuals below and above threshold cytokine levels are available.

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Open Access | Methodology: Haemoglobin interference and increased sensitivity of fluorimetric assays for quantification of low-parasitaemia Plasmodium infected erythrocytes

December 14, 2009 - 11:07 -- Ingeborg van Schayk
Author(s): 
Carlos Moneriz, Patricica Marin-Garcia, Jose M Bautista, Amalia Diez, Antonio Puyet
Reference: 
Malaria Journal 2009, 8:279 (4 December 2009)

The use of PG microassays on detergent-free, haemoglobin-depleted samples appears as the best choice both for the detection of Plasmodium in low-density infections and anti-malarial drugs tests.

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