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primate

Review: Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

October 25, 2009 - 16:56 -- Bart G.J. Knols
Author(s): 
Robert L. Clark
Reference: 
Reproductive Toxicology, Volume 28, Issue 3, November 2009, Pages 285-296, doi:10.1016/j.reprotox.2009.05.002

Single oral doses of artesunate, dihydroartemisinin, arteether and artemether administered to rats during a sensitive period of organogenesis caused embryo deaths and malformations (malformed long bones and ventricular septal defects). Extended oral dosing (12 days or more) of monkeys once daily with 12 mg/kg-d artesunate also caused embryo deaths. The initial embryotoxic effect in both species was to kill primitive erythroblasts which are present in the embryo for a few days of gestation in rats and several weeks in primates.

 

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Identification of Plasmodium malariae, a Human Malaria Parasite, in Imported Chimpanzees

October 25, 2009 - 15:51 -- Bart G.J. Knols
Author(s): 
Hayakawa T, Arisue N, Udono T, Hirai H, Sattabongkot J, et al.
Reference: 
PLoS ONE 4(10): e7412. doi:10.1371/journal.pone.0007412

It is widely believed that human malaria parasites infect only man as a natural host. However, earlier morphological observations suggest that great apes are likely to be natural reservoirs as well. To identify malaria parasites in great apes, we screened 60 chimpanzees imported into Japan.

 

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Book review: Review of "Primate Parasite Ecology: The dynamics and study of host-parasite relationships" by Michael A. Huffman and Colin A. Chapman (Eds.)

October 25, 2009 - 15:45 -- Bart G.J. Knols
Author(s): 
Poinar G
Reference: 
Parasites & Vectors 2009, 2:49 (16 October 2009)

Book review of "Primate Parasite Ecology: The dynamics and study of host-parasite relationships" by Michael A. Huffman and Colin A. Chapman (Eds.)

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