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pharmacokinetics

Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics

March 13, 2012 - 14:07 -- Patrick Sampao
Author(s): 
Deepthi Pabbisetty, Anuradha Illendula, K.M. Muraleedharan, Amar G. Chittiboyina, John S. Williamson, Mitchell A. Avery, Bonnie A. Avery
Reference: 
Journal of Chromatography B, Volumes 889–890, 15 March 2012, Pages 123-129

MalariaWorldThe analysis was carried out on an Acquity™ UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) with a flow rate of 0.3 mL/min. The detection was performed on a triple quadrupole tandem mass spectrometer in positive electrospray ionization (ESI) mode.

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Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Azithromycin in Healthy Volunteers

August 18, 2011 - 14:58 -- Patrick Sampao
Author(s): 
Nguyen Trong Chinh, Nguyen Ngoc Quang, Michael D. Edstein, et al.
Reference: 
Antimicrobial Agents and Chemotherapy, September 2011,p. 4412-4415, Vol. 55, No. 9

In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported.

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Open Access | Pharmacokinetics and Disposition: Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

January 14, 2011 - 12:37 -- Patrick Sampao
Author(s): 
Elizabeth A. Ashley., Kasia Stepniewska.,François Nosten., et al.
Reference: 
European Journal of Clinical Pharmacology, Volume 66, Number 7, 705-712

The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.

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Open Access | Research: Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

April 16, 2010 - 08:07 -- Kabogo Ndegwa
Author(s): 
J. Brian de Souza, Uduak Okomo,Michael Walther, et al.
Reference: 
PLoS ONE 5(4): e9867

If future studies succeed in establishing the efficacy of oAC in human malaria, then the characteristics of being inexpensive, well-tolerated at high doses and requiring no sophisticated storage would make oAC a relevant candidate for adjunct therapy to reduce mortality from severe malaria, or for immediate treatment of suspected severe malaria in a rural setting.

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Population Pharmacokinetics and Pharmacodynamic considerations of Amodiaquine and Desethylamodiaquine in Kenyan Adults with uncomplicated malaria receiving the Artesunate-Amodiaquine combination therapy

April 8, 2010 - 14:44 -- Patrick Sampao
Author(s): 
Jullien V, Ogutu B, Juma E, Carn G, Obyono C, Kiechel JR.
Reference: 
Antimicrob Agents Chemother. 2010 Apr 5

Despite its widespread use, the simultaneous pharmacokinetics of AQ and its active metabolite, desethylamodiaquine (DAQ) were not characterized to date in patients. This study provided the first simultaneous pharmacokinetic model for AQ and DAQ.

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Pharmacology: Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy

February 25, 2010 - 20:54 -- Kabogo Ndegwa
Author(s): 
Harin A. Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law,1 Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F. Ilett, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1186-1192, Volume 54, No. 3

Reduced plasma concentrations of both CQ and DECQ could compromise both curative efficacy and posttreatment prophylactic properties in pregnant patients. Higher IPTp CQ doses may be desirable but could increase the risk of adverse hemodynamic effects.

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Open Access | Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

December 23, 2009 - 21:47 -- Ingeborg van Schayk
Author(s): 
Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Carl Craft, Lawrence Fleckenstein
Reference: 
Malaria Journal 2009, 8:304 (18 December 2009)

The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food.

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Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects

November 10, 2009 - 20:57 -- Ingeborg van Schayk
Author(s): 
Vu Quoc Binh, Nguyen Trong Chinh, Nguyen Xuan Thanh, Bui Tri Cuong, Nguyen Ngoc Quang, Bui Dai, Thomas Travers, AND Michael D. Edstein
Reference: 
Am J Trop Med Hyg 2009;81 747-753

The primaquine pharmacokinetic data suggest that women have increased exposure to primaquine, which may put them at increased risk for toxicity when administered the same maintenance dose as men. The similar pharmacokinetics of doxycycline between the two sexes justifies the same maintenance dose.

 

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Review: Understanding the pharmacokinetics of Coartem®

October 25, 2009 - 15:03 -- Bart G.J. Knols
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Author(s): 
Abdoulaye Djimdé, Gilbert Lefèvre
Reference: 
Malaria Journal 2009, 8(Suppl 1):S4 (12 October 2009)

In conclusion, knowledge of the pharmacokinetic profiles of artemether and lumefantrine is increasing within a range of settings, including infants and children. However, additional data would be warranted to better characterize artemether and lumefantrine pharmacokinetics in patients with hepatic impairment, in pregnant women, and in patients undergoing HIV/AIDS chemotherapy.

 

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