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NOT Open Access | Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

March 9, 2020 - 14:24 -- NOT Open Access
Woodford J, Yeo TW, Piera KA, Butler K, Weinberg JB, McCarthy JS, Anstey NM, Barber BE
Infect Immun. 2020 Mar 2. pii: IAI.00895-19

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced P. falciparum and P. vivax infection.

NOT Open Access | Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway

January 15, 2020 - 08:01 -- NOT Open Access
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life Sciences, Volume 242, 1 February 2020, 117221

Endothelial cell (EC) tube formation is crucial for tumor angiogenesis, which becomes a target for chemotherapy. The anti-malaria agent dihydroartemisinin (DHA) inhibited tumor growth and angiogenesis. The aim of this study was to investigate the effects of DHA on EC tube formation and the underlying mechanisms.

Release of endothelial activation markers in lungs of patients with malaria-associated acute respiratory distress syndrome

December 10, 2019 - 08:11 -- Open Access
Thao-Thy Pham, Chuchard Punsawad, Supattra Glaharn, Simon F. De Meyer, Parnpen Viriyavejakul and Philippe E. Van den Steen
Malaria Journal 2019 18:395, 3 December 2019

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an understudied complication of malaria and is characterized by pulmonary inflammation and disruption of the alveolar-capillary membrane. Its pathogenesis remains poorly understood. Since endothelial activation plays an important role in other malarial complications, the expression of two endothelial activation markers, von Willebrand factor (VWF) and angiopoietin-2 (ANG-2), was investigated in the lungs of patients with MA-ARDS.

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