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Niger

Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger

January 6, 2021 - 11:36 -- Open Access
Author(s): 
Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa and Jean Louis Abdourahim Ndiaye
Reference: 
Malaria Journal 2021 20:1, 1 January 2021

In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. This paper evaluates the effect of SMC with SPAQ on antibody concentration in young children from Niger.

Malaria Parasitemia and Nutritional Status during the Low Transmission Season in the Presence of Azithromycin Distribution among Preschool Children in Niger

February 24, 2020 - 13:45 -- Open Access
Author(s): 
Arzika AM, Maliki R, Boubacar N, Kane S, Cook CA, Lebas E, Lin Y, O'Brien KS, Austin A, Keenan JD, Lietman TM, Oldenburg CE, For The Mordor Study Group
Reference: 
Am J Trop Med Hyg. 2020 Feb 17

The relationship between malaria and malnutrition is complicated, and existence of one may predispose or exacerbate the other. We evaluated the relationship between malaria parasitemia and nutritional status in children living in communities participating in a cluster-randomized trial of biannual azithromycin compared with placebo for prevention of childhood mortality. Data were collected during the low malaria transmission and low food insecurity season.

Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger

December 30, 2019 - 15:06 -- Open Access
Author(s): 
Matthew E. Coldiron, Bachir Assao, Rebecca F. Grais, et al.
Reference: 
Malaria Journal 2019 18:443, 26 December 2019

Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity. HRP2 tests can remain positive for weeks after treatment, limiting their specificity and usefulness in high-transmission settings. Tests using Plasmodium lactate dehydrogenase (pLDH) have been less widely used but have higher specificity, mostly due to a much shorter time to become negative.

Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial

December 9, 2019 - 16:16 -- Open Access
Author(s): 
Catherine E. Oldenburg, Abdou Amza, Gretchen Cooley, Boubacar Kadri, Beido Nassirou, Benjamin F. Arnold, Philip J. Rosenthal, Kieran S. O’Brien, Sheila K. West, Robin L. Bailey, Travis C. Porco, Jeremy D. Keenan, Thomas M. Lietman and Diana L. Martin
Reference: 
Malaria Journal 2019 18:389, 3 December 2019

Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-119), a surrogate for malaria incidence, was evaluated among children in Niger.

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