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Colombia

Malaria risk stratification in Colombia 2010 to 2019

March 17, 2021 - 17:17 -- Open Access
Author(s): 
Padilla-Rodríguez JC, Olivera MJ, Ahumada-Franco ML, Paredes-Medina AE
Reference: 
PLoS One. 2021 Mar 11;16(3):e0247811

Heterogeneity and focalization are the most common epidemiological characteristics of endemic countries in the Americas, where malaria transmission is moderate and low. During malaria elimination, the first step is to perform a risk stratification exercise to prioritize interventions. This study aimed to identify malaria risk strata in the ecoepidemiological regions of Colombia.

NOT Open Access | Malaria among migrants in a university hospital in Colombia during 2018: A case series

December 30, 2020 - 13:47 -- NOT Open Access
Author(s): 
Carreño-Almánzar FR, Coronado-Galán A, Cala-Gómez SA, Vega-Vera A
Reference: 
Trop Doct. 2020 Dec 23:49475520981301

Imported malaria has increased in Colombia since 2015 and has been attributed to migrants coming from Venezuela. We present a series of malaria cases, nested in a retrospective cross-sectional study between 2017 and 2018, aimed at calculating the prevalence of medical diseases among immigrants in a University Hospital in Colombia.

NOT Open Access | Association of variants in IL1B, TLR9, TREM1, IL10RA, and CD3G and Native American ancestry on malaria susceptibility in Colombian populations

December 16, 2020 - 09:44 -- NOT Open Access
Author(s): 
Mario-Vásquez JE, Naranjo-González CA, Montiel J, Zuluaga LM, Vásquez AM, Tobón-Castaño A, Bedoya G, Segura C
Reference: 
Infect Genet Evol. 2020 Dec 11:104675

Host genetics is an influencing factor in the manifestation of infectious diseases. In this study, the association of mild malaria with 28 variants in 16 genes previously reported in other populations and/or close to ancestry-informative markers (AIMs) selected was evaluated in an admixed 736 Colombian population sample. Additionally, the effect of genetic ancestry on phenotype expression was explored.

NOT Open Access | State of Artemisinin and Partner Drug Susceptibility in Plasmodium falciparum Clinical Isolates from Colombia

December 9, 2020 - 07:51 -- NOT Open Access
Author(s): 
Montenegro LM, de Las Salas B, Neal AT, Tobon-Castaño A, Fairhurst RM, Lopera-Mesa TM
Reference: 
Am J Trop Med Hyg. 2020 Dec 7

Delayed parasite clearance time observed in Southeast Asia provided the first evidence of Plasmodium falciparum resistance to artemisinins. The ex vivo ring-stage survival assay (RSA) mimics parasite exposure to pharmacologically relevant artemisinin concentrations. Mutations in the C-terminal propeller domain of the putative kelch protein Pf3D7_1343700 (K13) are associated with artemisinin resistance.

Strategies for malaria elimination: an Afro-Colombian perspective

November 19, 2020 - 13:00 -- Open Access
Author(s): 
Knudson-Ospina A, Barreto-Zorza YM, Castillo CF, Y Mosquera L, Apráez-Ippolito G, Olaya-Másmela LA, Piamba AH, Sanchez R
Reference: 
Rev Salud Publica (Bogota). 2020 Nov 13;21(1):9-16

To describe strategies for malaria elimination based on the perception of Afro-Colombian residents in Guapi, in the context of the Integrated Management Strategy for the Promotion, Prevention and Control of Vector-Borne Diseases in Colombia (EGI-ETV).

Cost-effectiveness of rapid diagnostic tests, compared to microscopic tests, for the diagnosis and treatment of gestational malaria in Colombia from an institutional perspective

November 11, 2020 - 14:22 -- Open Access
Author(s): 
Deisy Cristina Restrepo-Posada, Jaime Carmona-Fonseca and Jaiberth Antonio Cardona-Arias
Reference: 
Malaria Journal 2020 19:400, 10 November 2020

Gestational malaria is associated with negative outcomes in maternal and gestational health; timely diagnosis is crucial to avoid complications. However, the limited infrastructure, equipment, test reagents, and trained staff make it difficult to use thick blood smear tests in rural areas, where rapid testing could be a viable alternative. The purpose of this study was to estimate the cost-effectiveness of rapid tests type III (Plasmodium falciparum/Plasmodium spp P.f/pan) versus microscopic tests for the diagnosis and treatment of gestational malaria in Colombia.

Effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic region

October 20, 2020 - 16:05 -- Open Access
Author(s): 
Hernández-Valencia JC, Rincón DS, Marín A, Naranjo-Díaz N, Correa MM
Reference: 
PLoS One. 2020 Oct 15;15(10):e0240207

Landscape structure influences the distribution and abundance of anopheline mosquitoes and has an indirect impact on malaria transmission. This work aimed to determine the effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic area, the Bajo Cauca region.

Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia

August 4, 2020 - 15:37 -- Open Access
Author(s): 
Vásquez AM, Vélez G, Medina A, Serra-Casas E, Campillo A, Gonzalez IJ, Murphy SC, Seilie AM, Ding XC, Tobón Castaño A
Reference: 
BMC Pregnancy Childbirth. 2020 Jul 31;20(1):440

In low transmission settings early diagnosis is the main strategy to reduce adverse outcomes of malaria in pregnancy; however, microscopy and rapid diagnostic tests (RDTs) are inadequate for detecting low-density infections. We studied the performance of the highly sensitive-RDT (hsRDT) and the loop mediated isothermal DNA amplification (LAMP) for the detection of P. falciparum in pregnant women.

Parasite density in severe malaria in Colombia

June 26, 2020 - 15:31 -- Open Access
Author(s): 
Padilla-Rodríguez JC, Olivera MJ, Guevara-García BD
Reference: 
PLoS One. 2020 Jun 23;15(6):e0235119

Colombia has officially adopted the parasite density levels of severe malaria established by the WHO (>50,000 parasites/μl). These values have been inferred from areas of high transmission in Africa and are not consistent with the dynamics of low and unstable transmission in Colombia. The objective of this study was therefore to determine the parasite density values observed in patients with severe malaria and their distribution in the different ecoepidemiological regions of Colombia.

Potential negative effects of the free use of chloroquine to manage COVID-19 in Colombia

May 27, 2020 - 14:07 -- Open Access
Author(s): 
Teherán AA, Camero G, Hernández C, Perez-Garcia L, Gúzman R, Paniz-Mondolfi A, Ramírez JD
Reference: 
J Med Virol. 2020 May 26

Coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems around the world. Unfortunately, failure has ensued: high-income countries have succumbed to the global emergency despite highly prepared human and technological assets. There is no current consensus on pharmacological management of COVID-19, but chloroquine phosphate (CQ) has emerged as a possible therapeutical candidate.

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