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Effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic region

October 20, 2020 - 16:05 -- Open Access
Hernández-Valencia JC, Rincón DS, Marín A, Naranjo-Díaz N, Correa MM
PLoS One. 2020 Oct 15;15(10):e0240207

Landscape structure influences the distribution and abundance of anopheline mosquitoes and has an indirect impact on malaria transmission. This work aimed to determine the effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic area, the Bajo Cauca region.

Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia

August 4, 2020 - 15:37 -- Open Access
Vásquez AM, Vélez G, Medina A, Serra-Casas E, Campillo A, Gonzalez IJ, Murphy SC, Seilie AM, Ding XC, Tobón Castaño A
BMC Pregnancy Childbirth. 2020 Jul 31;20(1):440

In low transmission settings early diagnosis is the main strategy to reduce adverse outcomes of malaria in pregnancy; however, microscopy and rapid diagnostic tests (RDTs) are inadequate for detecting low-density infections. We studied the performance of the highly sensitive-RDT (hsRDT) and the loop mediated isothermal DNA amplification (LAMP) for the detection of P. falciparum in pregnant women.

Parasite density in severe malaria in Colombia

June 26, 2020 - 15:31 -- Open Access
Padilla-Rodríguez JC, Olivera MJ, Guevara-García BD
PLoS One. 2020 Jun 23;15(6):e0235119

Colombia has officially adopted the parasite density levels of severe malaria established by the WHO (>50,000 parasites/μl). These values have been inferred from areas of high transmission in Africa and are not consistent with the dynamics of low and unstable transmission in Colombia. The objective of this study was therefore to determine the parasite density values observed in patients with severe malaria and their distribution in the different ecoepidemiological regions of Colombia.

Potential negative effects of the free use of chloroquine to manage COVID-19 in Colombia

May 27, 2020 - 14:07 -- Open Access
Teherán AA, Camero G, Hernández C, Perez-Garcia L, Gúzman R, Paniz-Mondolfi A, Ramírez JD
J Med Virol. 2020 May 26

Coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems around the world. Unfortunately, failure has ensued: high-income countries have succumbed to the global emergency despite highly prepared human and technological assets. There is no current consensus on pharmacological management of COVID-19, but chloroquine phosphate (CQ) has emerged as a possible therapeutical candidate.

NOT Open Access | Spatial fine-resolution model of malaria risk for the Colombian Pacific region

May 19, 2020 - 15:26 -- NOT Open Access
Piedrahita S, Altamiranda-Saavedra M, Correa MM
Trop Med Int Health. 2020 May 17

To categorize and map, at high resolution, the risk of malaria incidence in the Pacific region, the main malaria‐endemic region of Colombia.

Microscopic and submicroscopic Plasmodium infections in indigenous and non-indigenous communities in Colombia

April 20, 2020 - 09:03 -- Open Access
Jehidys Montiel, Lina M. Zuluaga, Daniel C. Aguirre, Cesar Segura, Alberto Tobon-Castaño and Ana M. Vásquez
Malaria Journal 2020 19:157, 16 April 2020

The indigenous population is considered a highly susceptible group to malaria because individuals usually live in areas with high exposure to Anopheles and poverty, and have limited access to health services. There is a great diversity of indigenous communities in Colombia living in malaria-endemic areas; however, the burden of infection in these populations has not been studied extensively. This study aimed to determine the prevalence of Plasmodium infections in indigenous and non-indigenous communities in two malaria-endemic areas in Colombia.

Not Open Access | Artemether-Lumefantrine Efficacy for the Treatment of Uncomplicated Plasmodium falciparum Infection in Choco, Colombia after 8 Years as First-Line Treatment

March 3, 2020 - 12:27 -- NOT Open Access
Olivera MJ, Guerra AP, Macedo de Oliveira A, et al.
Am J Trop Med Hyg. 2020 Feb 24

Artemether–lumefantrine (AL) is the first-line treatment for uncomplicated Plasmodium falciparum infection in Colombia. To assess AL efficacy for uncomplicated falciparum malaria in Quibdo, Choco, Colombia, we conducted a 28-day therapeutic efficacy study (TES) following the WHO guidelines. From July 2018 to February 2019, febrile patients aged 5–65 years with microscopy-confirmed P. falciparum mono-infection and asexual parasite density of 250–100,000 parasites/µL were enrolled and treated with a supervised 3-day course of AL.

IgG antibody response against Anopheles salivary gland proteins in asymptomatic Plasmodium infections in Narino, Colombia

January 27, 2020 - 13:37 -- Open Access
Jehidys Montiel, Luisa F. Carbal, Alberto Tobón-Castaño, Gissella M. Vásquez, Michael L. Fisher and Berlin Londono-Rentería
Malaria Journal 2020 19:42, 23 January 2020

The humoral immune response against Anopheles salivary glands proteins in the vertebrate host can reflect the intensity of exposure to Anopheles bites and the risk of Plasmodium infection. In Colombia, the identification of exposure biomarkers is necessary due to the several Anopheles species circulating. The purpose of this study was to evaluate risk of malaria infection by measuring antibody responses against salivary glands extracts from Anopheles (Nyssorhynchus) albimanus and Anopheles (Nys.) darlingi and also against the gSG6-P1 peptide of Anopheles gambiae in people residing in a malaria endemic area in the Colombian Pacific coast.

Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia

December 9, 2019 - 15:35 -- Open Access
Lorena I. Orjuela, Diego A. Álvarez-Diaz, Juliana A. Morales, Nelson Grisales, Martha L. Ahumada, Juan Venegas H, Martha L. Quiñones and María F. Yasnot
Malaria Journal 2019 18:384, 2 December 2019

Knockdown resistance (kdr) is a well-characterized target-site insecticide resistance mechanism that is associated with DDT and pyrethroid resistance. Even though insecticide resistance to pyrethroids and DDT have been reported in Anopheles albimanus, Anopheles benarrochi sensu lato (s.l.), Anopheles darlingi, Anopheles nuneztovari s.l., and Anopheles pseudopunctipennis s.l. malaria vectors in Latin America, there is a knowledge gap on the role that kdr resistance mechanisms play in this resistance. The aim of this study was to establish the role that kdr mechanisms play in pyrethroid and DDT resistance in the main malaria vectors in Colombia, in addition to previously reported metabolic resistance mechanisms, such as mixed function oxidases (MFO) and nonspecific esterases (NSE) enzyme families.

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