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knockdown mutations

Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia

December 9, 2019 - 15:35 -- Open Access
Author(s): 
Lorena I. Orjuela, Diego A. Álvarez-Diaz, Juliana A. Morales, Nelson Grisales, Martha L. Ahumada, Juan Venegas H, Martha L. Quiñones and María F. Yasnot
Reference: 
Malaria Journal 2019 18:384, 2 December 2019

Knockdown resistance (kdr) is a well-characterized target-site insecticide resistance mechanism that is associated with DDT and pyrethroid resistance. Even though insecticide resistance to pyrethroids and DDT have been reported in Anopheles albimanus, Anopheles benarrochi sensu lato (s.l.), Anopheles darlingi, Anopheles nuneztovari s.l., and Anopheles pseudopunctipennis s.l. malaria vectors in Latin America, there is a knowledge gap on the role that kdr resistance mechanisms play in this resistance. The aim of this study was to establish the role that kdr mechanisms play in pyrethroid and DDT resistance in the main malaria vectors in Colombia, in addition to previously reported metabolic resistance mechanisms, such as mixed function oxidases (MFO) and nonspecific esterases (NSE) enzyme families.

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