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asymptomatic

Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana

December 8, 2020 - 10:05 -- Open Access
Author(s): 
Myers-Hansen JL, Abuaku B, Oyebola MK, Mensah BA, Ahorlu C, Wilson MD, Awandare G, Koram KA, Ngwa AA, Ghansah A
Reference: 
PLoS One. 2020 Dec 7;15(12):e0233478

Drug resistance remains a concern for malaria control and elimination. The effect of interventions on its prevalence needs to be monitored to pre-empt further selection. We assessed the prevalence of Plasmodium falciparum gene mutations associated with resistance to the antimalarial drugs: sulfadoxine-pyrimethamine (SP), chloroquine (CQ) and artemisinin combination therapy (ACTs) after the scale-up of a vector control activity that reduced transmission.

Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso

December 3, 2020 - 12:24 -- Open Access
Author(s): 
Kaboré B, Post A, Berendsen MLT, Diallo S, Lompo P, Derra K, Rouamba E, Jacobs J, Tinto H, de Mast Q, van der Ven AJ
Reference: 
PLoS One. 2020 Nov 30;15(11):e0242507

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive analysis of RBC hemostasis. Complete blood counts were analysed in subjects from all age groups (n = 1118) living in a malaria hyperendemic area and cytokines and iron biomarkers were also measured. Subjects were divided into age groups (<2 years, 2-4, 5-14 and ≥15 years old) and clinical categories (smear-negative healthy subjects, asymptomatic malaria and clinical malaria).

Evaluation of a single screen and treat strategy to detect asymptomatic malaria among pregnant women from selected health facilities in Lindi region, Tanzania

December 2, 2020 - 07:46 -- Open Access
Author(s): 
Chonge Kitojo, Frank Chacky, Emmanuel S. Kigadye, Joseph P. Mugasa, Abdallah Lusasi, Ally Mohamed, Patrick Walker, Erik J. Reaves, Julie R. Gutman and Deus S. Ishengoma
Reference: 
Malaria Journal 2020 19:438, 30 November 2020

In areas of high transmission, malaria in pregnancy (MiP) primarily causes asymptomatic infections; these infections nonetheless increase the risk of adverse maternal and fetal outcomes. In 2014, Tanzania initiated a single screening and treatment (SST) strategy for all pregnant women at their first antenatal care (ANC) visit using malaria rapid diagnostic tests (RDT) for surveillance purposes. However, there is paucity of data on the effectiveness of SST in the prevention of MiP. The objective of this study was to estimate the number of asymptomatic infections among pregnant women detected by SST, which would have been missed in the absence of the policy.

NOT Open Access | Association of TNF (rs1800629) promoter polymorphism and schistosomiasis with sub-microscopic asymptomatic Plasmodium falciparum infections in a schistosomiasis-endemic area in Zimbabwe

November 18, 2020 - 11:55 -- NOT Open Access
Author(s): 
Vengesai A, Marume A, Midzi H, Kasambala M, Naicker T, Mduluza T
Reference: 
Trop Med Int Health. 2020 Nov 15

Infection with P. falciparum parasites may result in a wide spectrum of symptoms ranging from asymptomatic to mild or severe. A number of factors are associated with this heterogeneous response to P. falciparum infection. In the present study, associations between sub‐microscopic asymptomatic P. falciparum with Schistosoma species and TNF (rs1800629) polymorphism were investigated.

Prevalence and Risk Factors of Asymptomatic Plasmodium Infection in Gondar Zuria District, Northwest Ethiopia

November 14, 2020 - 16:38 -- Open Access
Author(s): 
Minwuyelet A, Eshetu T, Milikit D, Aschale Y
Reference: 
Infect Drug Resist. 2020 Nov 4;13:3969-3975

Malaria is one of the major public health problems worldwide. In Ethiopia, an increase in malaria incidence may be attributed to the presence of community-wide asymptomatic Plasmodium infection. This study aims to assess asymptomatic Plasmodium infection and associated factors in Gondar Zuria district, Northwest Ethiopia.

NOT Open Access | Ultrasensitive diagnostics for low density asymptomatic Plasmodium falciparum infections in low transmission settings

November 7, 2020 - 13:00 -- NOT Open Access
Author(s): 
Zainabadi K
Reference: 
J Clin Microbiol. 2020 Nov 4:JCM.01508-20

The emergence of multidrug resistant Plasmodium falciparum malaria in Southeast Asia has accelerated regional malaria elimination efforts. Most malaria in this and other low transmission settings exists in asymptomatic individuals, which conventional diagnostic tests lack the sensitivity to detect. This has led to the development of new ultrasensitive diagnostics that are capable of detecting these low parasitemic infections.

NOT Open Access | Point-of-care tests for malaria: speeding up the diagnostics at the bedside and challenges in malaria cases detection

November 4, 2020 - 15:54 -- NOT Open Access
Author(s): 
Rei Yan SL, Wakasuqui F, Wrenger C
Reference: 
Diagn Microbiol Infect Dis. 2020 Nov;98(3):115122

Malaria remains as one of the major public health problems worldwide. About 228 million cases occurred in 2018 only, with Africa bearing about 93% of the cases. Asymptomatic population carrying the various forms of the parasite Plasmodium in endemic areas plays an important role in the spread of the disease. To tackle this battle, more sensitive and precise detection kits for malaria are crucial to better control the number of new malaria cases.

Asymptomatic Plasmodium falciparum malaria prevalence among adolescents and adults in Malawi, 2015-2016

November 4, 2020 - 10:13 -- Open Access
Author(s): 
Topazian HM, Gumbo A, Juliano JJ, et al.
Reference: 
Sci Rep. 2020 Oct 30;10(1):18740

Malaria remains a significant cause of morbidity and mortality in Malawi, with an estimated 18-19% prevalence of Plasmodium falciparum in children 2-10 years in 2015-2016. While children report the highest rates of clinical disease, adults are thought to be an important reservoir to sustained transmission due to persistent asymptomatic infection.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 14, 2020 - 12:25 -- Open Access
Author(s): 
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Reference: 
Malaria Journal 2020 19:366, 14 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 13, 2020 - 12:43 -- Open Access
Author(s): 
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Reference: 
Malaria Journal 2020 19:366, 12 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

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