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Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017

May 6, 2021 - 07:24 -- Open Access
Toussaint Rouamba, Sékou Samadoulougou, Mady Ouédraogo, Hervé Hien, Halidou Tinto and Fati Kirakoya-Samadoulougou
Malaria Journal 2021 20:211, 1 May 2021

Malaria in endemic countries is often asymptomatic during pregnancy, but it has substantial consequences for both the mother and her unborn baby. During pregnancy, anaemia is an important consequence of malaria infection. In Burkina Faso, the intensity of malaria varies according to the season, albeit the prevalence of malaria and anaemia as well as their risk factors, during high and low malaria transmission seasons is underexplored at the household level.

Recent Molecular Assessment of Plasmodium vivax and Plasmodium falciparum Asymptomatic Infections in Botswana

May 5, 2021 - 11:52 -- Open Access
Motshoge T, Haiyambo DH, Quaye IK, et al.
Am J Trop Med Hyg. 2021 May 3:tpmd210083

In 2016, we reported the presence of Plasmodium vivax in Botswana through active case detection. A real-time PCR was used during a similar study in 10 districts to assess changes in the P. vivax prevalence. We assessed 1,614 children (2-13 years of age) for hemoglobin (Hb; g/dL) and Plasmodium parasites. The median age of all participants was 5.0 years (25th percentile, 3 years; 75th percentile, 8 years).

NOT Open Access | Antimalarial drug resistance markers in human immunodeficiency virus (HIV)-positive and HIV-negative adults with asymptomatic malaria infections in Port Harcourt, Nigeria

April 7, 2021 - 12:16 -- NOT Open Access
Chijioke-Nwauche I, Oguike MC, Nwauche CA, Beshir KB, Sutherland CJ
Trans R Soc Trop Med Hyg. 2021 Apr 6:trab061

In Nigeria, indiscriminate use of antimalarial drugs may contribute to the threat of drug resistance, but this has not been evaluated among people living with human immunodeficiency virus (HIV).

A systematic review and meta-analysis of asymptomatic malaria infection in pregnant women in Sub-Saharan Africa: A challenge for malaria elimination efforts

April 7, 2021 - 12:07 -- Open Access
Yimam Y, Nateghpour M, Mohebali M, Abbaszadeh Afshar MJ
PLoS One. 2021 Apr 1;16(4):e0248245

In Sub-Saharan Africa (SSA), where malaria transmission is stable, malaria infection in pregnancy adversely affects pregnant women, fetuses, and newborns and is often asymptomatic. So far, a plethora of primary studies have been carried out on asymptomatic malaria infection in pregnant women in SSA. Nevertheless, no meta-analysis estimated the burden of asymptomatic malaria infection in pregnant women in SSA, so this meta-analysis was carried out to bridge this gap.

School-based screening and treatment may reduce P. falciparum transmission

March 31, 2021 - 14:34 -- Open Access
Cohee LM, Valim C, Laufer MK, et al.
Sci Rep. 2021 Mar 25;11(1):6905

In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact screening-and-treatment of asymptomatic Malawian schoolchildren (n = 364 in the rainy season and 341 in the dry season) had on gametocyte-the parasite stage responsible for human-to-mosquito transmission-carriage.

Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children

March 30, 2021 - 14:05 -- Open Access
Abdullahi Ahmad, Aurelia Prom, John Bradley, Mamadou Ndiath, Blessed Etoketim, Mamadou Bah, Jean-Pierre Van Geertruyden, Chris Drakeley, Teun Bousema, Jane Achan and Umberto D’Alessandro
Malaria Journal 2021 20:169, 26 March 2021

Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage. The effect of seasonal malaria chemoprevention (SMC) with SP and AQ on gametocyte carriage was assessed in asymptomatic P. falciparum infected children.

NOT Open Access | Understanding Host-Pathogen-Vector Interactions with Chronic Asymptomatic Malaria Infections

March 2, 2021 - 15:37 -- NOT Open Access
Nyarko PB, Claessens A
Trends Parasitol. 2021 Mar;37(3):195-204

The last malaria parasite standing will display effective adaptations to selective forces. While substantial progress has been made in reducing malaria mortality, eradication will require elimination of all Plasmodium parasites, including those in asymptomatic infections. These typically chronic, low-density infections are difficult to detect, yet can persist for months.

High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana

February 20, 2021 - 08:35 -- Open Access
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari and Kwadwo A. Koram
Malaria Journal 2021 20:99, 17 February 2021

Recent studies from different malaria-endemic regions including western Africa have now shown that Plasmodium vivax can infect red blood cells (RBCs) and cause clinical disease in Duffy-negative people, though the Duffy-negative phenotype was thought to confer complete refractoriness against blood invasion with P. vivax. The actual prevalence of P. vivax in local populations in Ghana is unknown and little information is available about the distribution of Duffy genotypes. The aim of this study was to assess the prevalence of P. vivax in both asymptomatic and symptomatic outpatients and the distribution of Duffy genotypes in Ghana.

Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia

January 20, 2021 - 07:08 -- Open Access
Jaiteh F, Okebe J, Masunaga Y, D'Alessandro U, Achan J, Gryseels C, de Vries D, Ribera JM, Grietens KP
Sci Rep. 2021 Jan 18;11(1):1746

The impact of different types of reactive case detection and/or treatment strategies for malaria elimination depends on high coverage and participants' adherence. However, strategies to optimise adherence are limited, particularly for people with asymptomatic or no infections. As part of a cluster-randomized trial to evaluate the effect of reactive treatment in The Gambia, all residents in the compound of a diagnosed clinical malaria patient received dihydro-artemisinin-piperaquine (DP). Using a mixed method approach, we assessed which factors contribute to adherence among the contacts of malaria cases that showed no symptoms.

Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season

January 13, 2021 - 10:31 -- Open Access
Oduma CO, Ogolla S, Atieli H, Ondigo BN, Lee MC, Githeko AK, Dent AE, Kazura JW, Yan G, Koepfli C
BMC Infect Dis. 2021 Jan 9;21(1):44

Transmission stemming from asymptomatic infections is increasingly being recognized as a threat to malaria elimination. In many regions, malaria transmission is seasonal. It is not well understood whether Plasmodium falciparum modulates its investment in transmission to coincide with seasonal vector abundance.


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