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asymptomatic

NOT Open Access | Association of TNF (rs1800629) promoter polymorphism and schistosomiasis with sub-microscopic asymptomatic Plasmodium falciparum infections in a schistosomiasis-endemic area in Zimbabwe

November 18, 2020 - 11:55 -- NOT Open Access
Author(s): 
Vengesai A, Marume A, Midzi H, Kasambala M, Naicker T, Mduluza T
Reference: 
Trop Med Int Health. 2020 Nov 15

Infection with P. falciparum parasites may result in a wide spectrum of symptoms ranging from asymptomatic to mild or severe. A number of factors are associated with this heterogeneous response to P. falciparum infection. In the present study, associations between sub‐microscopic asymptomatic P. falciparum with Schistosoma species and TNF (rs1800629) polymorphism were investigated.

Prevalence and Risk Factors of Asymptomatic Plasmodium Infection in Gondar Zuria District, Northwest Ethiopia

November 14, 2020 - 16:38 -- Open Access
Author(s): 
Minwuyelet A, Eshetu T, Milikit D, Aschale Y
Reference: 
Infect Drug Resist. 2020 Nov 4;13:3969-3975

Malaria is one of the major public health problems worldwide. In Ethiopia, an increase in malaria incidence may be attributed to the presence of community-wide asymptomatic Plasmodium infection. This study aims to assess asymptomatic Plasmodium infection and associated factors in Gondar Zuria district, Northwest Ethiopia.

NOT Open Access | Ultrasensitive diagnostics for low density asymptomatic Plasmodium falciparum infections in low transmission settings

November 7, 2020 - 13:00 -- NOT Open Access
Author(s): 
Zainabadi K
Reference: 
J Clin Microbiol. 2020 Nov 4:JCM.01508-20

The emergence of multidrug resistant Plasmodium falciparum malaria in Southeast Asia has accelerated regional malaria elimination efforts. Most malaria in this and other low transmission settings exists in asymptomatic individuals, which conventional diagnostic tests lack the sensitivity to detect. This has led to the development of new ultrasensitive diagnostics that are capable of detecting these low parasitemic infections.

NOT Open Access | Point-of-care tests for malaria: speeding up the diagnostics at the bedside and challenges in malaria cases detection

November 4, 2020 - 15:54 -- NOT Open Access
Author(s): 
Rei Yan SL, Wakasuqui F, Wrenger C
Reference: 
Diagn Microbiol Infect Dis. 2020 Nov;98(3):115122

Malaria remains as one of the major public health problems worldwide. About 228 million cases occurred in 2018 only, with Africa bearing about 93% of the cases. Asymptomatic population carrying the various forms of the parasite Plasmodium in endemic areas plays an important role in the spread of the disease. To tackle this battle, more sensitive and precise detection kits for malaria are crucial to better control the number of new malaria cases.

Asymptomatic Plasmodium falciparum malaria prevalence among adolescents and adults in Malawi, 2015-2016

November 4, 2020 - 10:13 -- Open Access
Author(s): 
Topazian HM, Gumbo A, Juliano JJ, et al.
Reference: 
Sci Rep. 2020 Oct 30;10(1):18740

Malaria remains a significant cause of morbidity and mortality in Malawi, with an estimated 18-19% prevalence of Plasmodium falciparum in children 2-10 years in 2015-2016. While children report the highest rates of clinical disease, adults are thought to be an important reservoir to sustained transmission due to persistent asymptomatic infection.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 14, 2020 - 12:25 -- Open Access
Author(s): 
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Reference: 
Malaria Journal 2020 19:366, 14 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 13, 2020 - 12:43 -- Open Access
Author(s): 
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Reference: 
Malaria Journal 2020 19:366, 12 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

Comparison of leucocyte profiles between healthy children and those with asymptomatic and symptomatic Plasmodium falciparum infections

October 13, 2020 - 12:39 -- Open Access
Author(s): 
Diana Ahu Prah, Linda Eva Amoah, Matthew P. Gibbins, Yaw Bediako, Aubrey J. Cunnington, Gordon A. Awandare and Julius Clemence R. Hafalla
Reference: 
Malaria Journal 2020 19:364, 9 October 2020

The immune mechanisms that determine whether a Plasmodium falciparum infection would be symptomatic or asymptomatic are not fully understood. Several studies have been carried out to characterize the associations between disease outcomes and leucocyte numbers. However, the majority of these studies have been conducted in adults with acute uncomplicated malaria, despite children being the most vulnerable group.

NOT Open Access | Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria. Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation

October 7, 2020 - 15:43 -- NOT Open Access
Author(s): 
Bharti AR, McCutchan JA, Umlauf A, Okwuegbuna OK, Letendre S, Cherner M, Burdo T, Jumare J, Williams K, Blattner W, Royal W
Reference: 
J Acquir Immune Defic Syndr. 2020 Oct 1

HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults.

Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria

September 23, 2020 - 09:25 -- Open Access
Author(s): 
Lee RA, Puig H, Nguyen PQ, Angenent-Mari NM, Donghia NM, McGee JP, Dvorin JD, Klapperich CM, Pollock NR, Collins JJ
Reference: 
Proc Natl Acad Sci U S A. 2020 Sep 21:202010196

Asymptomatic carriers of Plasmodium parasites hamper malaria control and eradication. Achieving malaria eradication requires ultrasensitive diagnostics for low parasite density infections (<100 parasites per microliter blood) that work in resource-limited settings (RLS). Sensitive point-of-care diagnostics are also lacking for nonfalciparum malaria, which is characterized by lower density infections and may require additional therapy for radical cure.

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