The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10750 malaria professionals are enjoying the free benefits of MalariaWorld today

asymptomatic

NOT Open Access | Understanding Host-Pathogen-Vector Interactions with Chronic Asymptomatic Malaria Infections

March 2, 2021 - 15:37 -- NOT Open Access
Author(s): 
Nyarko PB, Claessens A
Reference: 
Trends Parasitol. 2021 Mar;37(3):195-204

The last malaria parasite standing will display effective adaptations to selective forces. While substantial progress has been made in reducing malaria mortality, eradication will require elimination of all Plasmodium parasites, including those in asymptomatic infections. These typically chronic, low-density infections are difficult to detect, yet can persist for months.

High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana

February 20, 2021 - 08:35 -- Open Access
Author(s): 
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari and Kwadwo A. Koram
Reference: 
Malaria Journal 2021 20:99, 17 February 2021

Recent studies from different malaria-endemic regions including western Africa have now shown that Plasmodium vivax can infect red blood cells (RBCs) and cause clinical disease in Duffy-negative people, though the Duffy-negative phenotype was thought to confer complete refractoriness against blood invasion with P. vivax. The actual prevalence of P. vivax in local populations in Ghana is unknown and little information is available about the distribution of Duffy genotypes. The aim of this study was to assess the prevalence of P. vivax in both asymptomatic and symptomatic outpatients and the distribution of Duffy genotypes in Ghana.

Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia

January 20, 2021 - 07:08 -- Open Access
Author(s): 
Jaiteh F, Okebe J, Masunaga Y, D'Alessandro U, Achan J, Gryseels C, de Vries D, Ribera JM, Grietens KP
Reference: 
Sci Rep. 2021 Jan 18;11(1):1746

The impact of different types of reactive case detection and/or treatment strategies for malaria elimination depends on high coverage and participants' adherence. However, strategies to optimise adherence are limited, particularly for people with asymptomatic or no infections. As part of a cluster-randomized trial to evaluate the effect of reactive treatment in The Gambia, all residents in the compound of a diagnosed clinical malaria patient received dihydro-artemisinin-piperaquine (DP). Using a mixed method approach, we assessed which factors contribute to adherence among the contacts of malaria cases that showed no symptoms.

Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season

January 13, 2021 - 10:31 -- Open Access
Author(s): 
Oduma CO, Ogolla S, Atieli H, Ondigo BN, Lee MC, Githeko AK, Dent AE, Kazura JW, Yan G, Koepfli C
Reference: 
BMC Infect Dis. 2021 Jan 9;21(1):44

Transmission stemming from asymptomatic infections is increasingly being recognized as a threat to malaria elimination. In many regions, malaria transmission is seasonal. It is not well understood whether Plasmodium falciparum modulates its investment in transmission to coincide with seasonal vector abundance.

Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities

December 16, 2020 - 09:51 -- Open Access
Author(s): 
Anabire NG, Aryee PA, Ziblim Z, Suurbaar J, Ansah F, Helegbe GK
Reference: 
BMC Infect Dis. 2020 Dec 14;20(1):957

Chronic Sedentary lifestyles have been linked to increased odds of stress, elevated anxiety and diminished wellbeing, inducing cytokine production and predispose to hypertension and other cardiovascular diseases. In endemic areas, Plasmodium falciparum and hepatitis B virus (HBV) infections can trigger pro-inflammatory cytokine responses. However, the impact of these infections on cytokine response profiles in individuals engaged in chronic sedentary activities is unknown. This study was aimed at addressing these concerns using a predominantly sedentary population of traders in the Tamale metropolis of Ghana.

Asymptomatic recrudescence after artemether–lumefantrine treatment for uncomplicated falciparum malaria: a systematic review and meta-analysis

December 15, 2020 - 16:04 -- Open Access
Author(s): 
Rida Mumtaz, Lucy C. Okell and Joseph D. Challenger
Reference: 
Malaria Journal 2020 19:453, 9 December 2020

In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as ‘clinical’ or ‘parasitological’ failures, the former indicating that symptoms have returned. Asymptomatic recrudescence has public health implications for continued malaria transmission and may be important for the spread of drug-resistant malaria. As the number of recrudescences in an individual trial is often low, it is difficult to assess how commonplace asymptomatic recrudescence is, and with what factors it is associated.

Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana

December 8, 2020 - 10:05 -- Open Access
Author(s): 
Myers-Hansen JL, Abuaku B, Oyebola MK, Mensah BA, Ahorlu C, Wilson MD, Awandare G, Koram KA, Ngwa AA, Ghansah A
Reference: 
PLoS One. 2020 Dec 7;15(12):e0233478

Drug resistance remains a concern for malaria control and elimination. The effect of interventions on its prevalence needs to be monitored to pre-empt further selection. We assessed the prevalence of Plasmodium falciparum gene mutations associated with resistance to the antimalarial drugs: sulfadoxine-pyrimethamine (SP), chloroquine (CQ) and artemisinin combination therapy (ACTs) after the scale-up of a vector control activity that reduced transmission.

Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso

December 3, 2020 - 12:24 -- Open Access
Author(s): 
Kaboré B, Post A, Berendsen MLT, Diallo S, Lompo P, Derra K, Rouamba E, Jacobs J, Tinto H, de Mast Q, van der Ven AJ
Reference: 
PLoS One. 2020 Nov 30;15(11):e0242507

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive analysis of RBC hemostasis. Complete blood counts were analysed in subjects from all age groups (n = 1118) living in a malaria hyperendemic area and cytokines and iron biomarkers were also measured. Subjects were divided into age groups (<2 years, 2-4, 5-14 and ≥15 years old) and clinical categories (smear-negative healthy subjects, asymptomatic malaria and clinical malaria).

Evaluation of a single screen and treat strategy to detect asymptomatic malaria among pregnant women from selected health facilities in Lindi region, Tanzania

December 2, 2020 - 07:46 -- Open Access
Author(s): 
Chonge Kitojo, Frank Chacky, Emmanuel S. Kigadye, Joseph P. Mugasa, Abdallah Lusasi, Ally Mohamed, Patrick Walker, Erik J. Reaves, Julie R. Gutman and Deus S. Ishengoma
Reference: 
Malaria Journal 2020 19:438, 30 November 2020

In areas of high transmission, malaria in pregnancy (MiP) primarily causes asymptomatic infections; these infections nonetheless increase the risk of adverse maternal and fetal outcomes. In 2014, Tanzania initiated a single screening and treatment (SST) strategy for all pregnant women at their first antenatal care (ANC) visit using malaria rapid diagnostic tests (RDT) for surveillance purposes. However, there is paucity of data on the effectiveness of SST in the prevention of MiP. The objective of this study was to estimate the number of asymptomatic infections among pregnant women detected by SST, which would have been missed in the absence of the policy.

NOT Open Access | Association of TNF (rs1800629) promoter polymorphism and schistosomiasis with sub-microscopic asymptomatic Plasmodium falciparum infections in a schistosomiasis-endemic area in Zimbabwe

November 18, 2020 - 11:55 -- NOT Open Access
Author(s): 
Vengesai A, Marume A, Midzi H, Kasambala M, Naicker T, Mduluza T
Reference: 
Trop Med Int Health. 2020 Nov 15

Infection with P. falciparum parasites may result in a wide spectrum of symptoms ranging from asymptomatic to mild or severe. A number of factors are associated with this heterogeneous response to P. falciparum infection. In the present study, associations between sub‐microscopic asymptomatic P. falciparum with Schistosoma species and TNF (rs1800629) polymorphism were investigated.

Pages

Subscribe to RSS - asymptomatic