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NOT Open Access | Activation of Artemisinin and Heme Degradation in Leishmania tarentolae Promastigotes: A Possible Link

December 2, 2019 - 14:57 -- NOT Open Access
Geroldinger G, Tonner M, Gille L, et al.
Biochem Pharmacol. 2019 Nov 28:113737

Endoperoxides (EPs) appear to be promising drug candidates against protozoal diseases, including malaria and leishmaniasis. Previous studies have shown that these drugs need an intracellular activation to exert their pharmacological potential. The efficiency of these drugs is linked to the extensive iron demand of these intracellular protozoal parasites.

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