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Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya

July 28, 2021 - 14:15 -- Open Access
Sumner KM, Mangeni JN, Obala AA, Freedman E, Abel L, Meshnick SR, Edwards JK, Pence BW, Prudhomme-O'Meara W, Taylor SM
Elife. 2021 Jul 23;10:e68812

Asymptomatic Plasmodium falciparum infections are common in sub-Saharan Africa, but their effect on subsequent symptomaticity is incompletely understood.

Not Open Access | First evidence of local circulation of Plasmodium ovale curtisi and reliability of a malaria rapid diagnostic test among symptomatic outpatients in Douala, Cameroon

July 6, 2021 - 14:16 -- NOT Open Access
Kojom Foko LP, Kouemo Motse FD, Kamgain Mawabo L, Pande V, Singh V
Infect Genet Evol. 2021 Jul;91:104797

The performances of a commonly used Plasmodium falciparum-detecting rapid diagnostic test (RDT) were determined in symptomatic individuals living in Cameroon. Discrepancies between RDT and light microscopy (LM) results were further investigated, with a focus on non-falciparum malaria (NFM) which are still largely understudied in sub-Saharan Africa (sSA) countries. In the present study, a total of 355 individuals aged 1-65 years were enrolled in the study. Their signs/symptoms and sociodemographic characteristics were documented.

Fine scale analysis of malaria incidence in under-5: hierarchical Bayesian spatio-temporal modelling of routinely collected malaria data between 2012-2018 in Cameroon

June 9, 2021 - 14:56 -- Open Access
Danwang C, Khalil É, Achu D, Ateba M, Abomabo M, Souopgui J, De Keukeleire M, Robert A
Sci Rep. 2021 Jun 1;11(1):11408

The current study aims to provide a fine-scale spatiotemporal estimate of malaria incidence among Cameroonian under-5, and to determine its associated environmental factors, to set up preventive interventions that are adapted to each health district of Cameroon. Routine data on symptomatic malaria in children under-5 collected in health facilities, between 2012 and 2018 were used.

Determinants of the varied profiles of Plasmodium falciparum infections among infants living in Kintampo, Ghana

June 5, 2021 - 06:18 -- Open Access
Akua Kyerewaa Botwe, Felix Boakye Oppong, Stephaney Gyaase, Seth Owusu-Agyei, Muhammad Asghar, Kwaku Poku Asante, Anna Färnert and Faith Osier
Malaria Journal 2021 20:240, 29 May 2021

Understanding why some infants tolerate infections, remaining asymptomatic while others succumb to repeated symptomatic malaria is beneficial for studies of naturally acquired immunity and can guide control interventions. This study compared demographic, host and maternal factors associated with being either parasite negative or having asymptomatic infections versus developing symptomatic malaria in the first year of life.

NOT Open Access | Exposure to diverse Plasmodium falciparum genotypes shapes the risk of symptomatic malaria in incident and persistent infections: A longitudinal molecular epidemiologic study in Kenya

April 29, 2021 - 07:56 -- NOT Open Access
Sumner KM, Freedman E, Taylor SM, et al.
Clin Infect Dis. 2021 Apr 27:ciab357

Repeated exposure to malaria infections could protect against symptomatic progression, as people develop adaptive immunity to infections acquired over time.

Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the Congo

March 24, 2021 - 15:08 -- Open Access
Parr JB, Kieto E, Kalonji A, et al.
Sci Rep. 2021 Mar 22;11(1):6495

The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false-negative RDT results due to parasites with deletions of the pfhrp2 and/or pfhrp3 genes (pfhrp2/3) raise concern about existing malaria diagnostic strategies. We previously identified pfhrp2-negative parasites among asymptomatic children in the Democratic Republic of the Congo (DRC), but their impact on diagnosis of symptomatic malaria is unknown.

NOT Open Access | Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

March 17, 2021 - 17:03 -- NOT Open Access
Holm AE, Gomes LC, Farias Marinho CR, Silvestre OM, Vestergaard LS, Biering-Sørensen T, Brainin P
Am J Trop Med Hyg. 2021 Mar 15:tpmd201414

Recent studies have suggested that malaria may affect the cardiovascular system. The aim of this systematic review and meta-analysis was to determine the prevalence of cardiovascular complications in symptomatic malaria patients. We searched databases such as Pubmed, Embase, Cochrane, and Web of Science (January 1950-April 2020) for studies reporting on cardiovascular complications in adults and children with malaria.

Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea

February 15, 2021 - 15:32 -- Open Access
Arndt L, Koleala T, Karl S, et al.
Nat Commun. 2021 Feb 12;12(1):969

Improved methods for malaria diagnosis are urgently needed. Here, we evaluate a novel method named rotating-crystal magneto-optical detection (RMOD) in 956 suspected malaria patients in Papua New Guinea. RMOD tests can be conducted within minutes and at low cost. We systematically evaluate the capability of RMOD to detect infections by directly comparing it with expert light microscopy, rapid diagnostic tests and polymerase chain reaction on capillary blood samples.

Malaria parasitaemia and mRDT diagnostic performances among symptomatic individuals in selected health care facilities across Ghana

February 3, 2021 - 14:09 -- Open Access
Abuaku B, Amoah LE, Peprah NY, Asamoah A, Amoako EO, Donu D, Adu GA, Malm KL
BMC Public Health. 2021 Jan 28;21(1):239

Parasitological diagnosis generates data to assist malaria-endemic countries determine their status within the malaria elimination continuum and also inform the deployment of proven interventions to yield maximum impact. This study determined prevalence of malaria parasitaemia and mRDT performances among febrile patients in selected health care facilities across Ghana.

Plasmodium cynomolgi Co-infections among Symptomatic Malaria Patients, Thailand

February 2, 2021 - 16:48 -- Open Access
Putaporntip C, Kuamsab N, Pattanawong U, Yanmanee S, Seethamchai S, Jongwutiwes S
Emerg Infect Dis. 2021 Feb;27(2):590-593

Among 1,180 symptomatic malaria patients, 9 (0.76%) infected with Plasmodium cynomolgi were co-infected with P. vivax (n = 7), P. falciparum (n = 1), or P. vivax and P. knowlesi (n = 1). Patients were from Tak, Chanthaburi, Ubon Ratchathani, Yala, and Narathiwat Provinces, suggesting P. cynomolgi is widespread in this country.


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