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plasmodium falciparum infections

Histopathological lesions and exposure to Plasmodium falciparum infections in the placenta increases the risk of preeclampsia among pregnant women

May 21, 2020 - 06:23 -- Open Access
Obiri D, Erskine IJ, Oduro D, Kusi KA, Amponsah J, Gyan BA, Adu-Bonsaffoh K, Ofori MF
Sci Rep. 2020 May 19; 10(1):8280

Preeclampsia (PE) is a placental disorder with different phenotypic presentations. In malaria-endemic regions, high incidence of PE is reported, with debilitating foeto-maternal effects, particularly among primigravid women. However, the relationship between placental pathology and Plasmodium falciparum infection in the placenta with PE is underexplored.

Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults

November 30, 2019 - 12:24 -- Open Access
Zoleko Manego R, Koehne E, Mombo-Ngoma G, et al.
Malar J. 2019 Nov 21;18(1):371

Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Adolescents and adults are reported to have acquired a semi-immune status and, therefore, present with low parasitaemia. Children are understood to present with a much higher parasitaemia and severe malaria. It is a concern that effective malaria control programmes targeting young children may lead to a delay in the acquisition of acquired immunity and, therefore, causing a shift in the epidemiology of malaria. Prevalence and parasitaemia were explored in adolescents and adults with Plasmodium falciparum infections compared to young children in the area of Lambaréné, Gabon as an indicator for semi-immunity. 

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