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long-term iron

Testing an infection model to explain excess risk of preterm birth with long-term iron supplementation in a malaria endemic area

December 2, 2019 - 14:45 -- Open Access
Author(s): 
Brabin B, Tinto H, Roberts SA
Reference: 
Malaria Journal volume 18, 374 (2019)

In view of recent evidence from a randomized trial in Burkina Faso that periconceptional iron supplementation substantially increases risk of spontaneous preterm birth (< 37 weeks) in first pregnancies (adjusted relative risk = 2.22; 95% CI 1.39–3.61), explanation is required to understand potential mechanisms, including progesterone mediated responses, linking long-term iron supplementation, malaria and gestational age.

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