Testing an infection model to explain excess risk of preterm birth with long-term iron supplementation in a malaria endemic area
Reference:
Malaria Journal volume 18, 374 (2019)
In view of recent evidence from a randomized trial in Burkina Faso that periconceptional iron supplementation substantially increases risk of spontaneous preterm birth (< 37 weeks) in first pregnancies (adjusted relative risk = 2.22; 95% CI 1.39–3.61), explanation is required to understand potential mechanisms, including progesterone mediated responses, linking long-term iron supplementation, malaria and gestational age.
