Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection
Reference:
PLoS Negl Trop Dis. 2019 Nov 21;13(11):e0007890.
Recent outbreaks of the Ebola virus (EBOV) have focused attention on the dire need for antivirals to treat these patients. We identified pyronaridine tetraphosphate as a potential candidate as it is an approved drug in the European Union which is currently used in combination with artesunate as a treatment for malaria (EC50 between 420 nM-1.14 μM against EBOV in HeLa cells).
