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hrp2

Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger

December 30, 2019 - 15:06 -- Open Access
Author(s): 
Matthew E. Coldiron, Bachir Assao, Rebecca F. Grais, et al.
Reference: 
Malaria Journal 2019 18:443, 26 December 2019

Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity. HRP2 tests can remain positive for weeks after treatment, limiting their specificity and usefulness in high-transmission settings. Tests using Plasmodium lactate dehydrogenase (pLDH) have been less widely used but have higher specificity, mostly due to a much shorter time to become negative.

Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study

November 26, 2019 - 20:43 -- Open Access
Author(s): 
Kreidenweiss A, Trauner F, Sandri TL, et al.
Reference: 
EBioMedicine. 2019 Nov 21. pii: S2352-3964(19)30723-6.

Plasmodium falciparum deficient for hrp2 and hrp3 genes are a threat to malaria management and elimination, since they escape widely used HRP2-based rapid diagnostic tests and treatment. Hrp2/hrp3 deletions are increasingly reported from all malaria endemic regions but are currently only identified by laborious methodologies.

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