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malaria rapid diagnostic tests

Economic considerations support C-reactive protein testing alongside malaria rapid diagnostic tests to guide antimicrobial therapy for patients with febrile illness in settings with low malaria endemicity

December 30, 2019 - 15:02 -- Open Access
Yoel Lubell, Arjun Chandna, Sabine Dittrich, et al.
Malaria Journal 2019 18:442, 26 December 2019

Malaria is no longer a common cause of febrile illness in many regions of the tropics. In part, this success is a result of improved access to accurate diagnosis and effective anti-malarial treatment, including in many hard-to-reach rural areas. However, in these settings, management of other causes of febrile illness remains challenging. Health systems are often weak and other than malaria rapid tests no other diagnostics are available.

Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study

November 26, 2019 - 20:43 -- Open Access
Kreidenweiss A, Trauner F, Sandri TL, et al.
EBioMedicine. 2019 Nov 21. pii: S2352-3964(19)30723-6.

Plasmodium falciparum deficient for hrp2 and hrp3 genes are a threat to malaria management and elimination, since they escape widely used HRP2-based rapid diagnostic tests and treatment. Hrp2/hrp3 deletions are increasingly reported from all malaria endemic regions but are currently only identified by laborious methodologies.

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