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architecture

The genomic architecture of antimalarial drug resistance

November 26, 2019 - 20:17 -- Open Access
Author(s): 
Annie N Cowell, Elizabeth A Winzeler
Reference: 
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 314–328

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to nearly all known antimalarials. The ability of malaria parasites to develop resistance is primarily due to the high numbers of parasites in the infected person’s bloodstream during the asexual blood stage of infection in conjunction with the mutability of their genomes.

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