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Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia

August 4, 2020 - 15:13 -- Open Access
Hocking SE, Divis PCS, Kadir KA, Singh B, Conway DJ
Emerg Infect Dis. 2020 Aug; 26(8):1749-1758

Most malaria in Malaysia is caused by Plasmodium knowlesi parasites through zoonotic infection from macaque reservoir hosts. We obtained genome sequences from 28 clinical infections in Peninsular Malaysia to clarify the emerging parasite population structure and test for evidence of recent adaptation. The parasites all belonged to a major genetic population of P. knowlesi (cluster 3) with high genomewide divergence from populations occurring in Borneo (clusters 1 and 2). genomic and transcriptomic database for Plasmodium species

January 15, 2020 - 14:47 -- Open Access
Tan QW, Mutwil M
Nucleic Acids Research, Volume 48, Issue D1, 08 January 2020, Pages D768–D775

Malaria is a tropical parasitic disease caused by the Plasmodium genus, which resulted in an estimated 219 million cases of malaria and 435 000 malaria-related deaths in 2017. Despite the availability of the Plasmodium falciparum genome since 2002, 74% of the genes remain uncharacterized. To remedy this paucity of functional information, we used transcriptomic data to build gene co-expression networks for two Plasmodium species (P. falciparum and P. berghei), and included genomic data of four other Plasmodium species, P. yoelii, P. knowlesi, P. vivax and P. cynomolgi, as well as two non-Plasmodium species from the Apicomplexa, Toxoplasma gondii and Theileria parva.

The genomic architecture of antimalarial drug resistance

November 26, 2019 - 20:17 -- Open Access
Annie N Cowell, Elizabeth A Winzeler
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 314–328

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to nearly all known antimalarials. The ability of malaria parasites to develop resistance is primarily due to the high numbers of parasites in the infected person’s bloodstream during the asexual blood stage of infection in conjunction with the mutability of their genomes.

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