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gene regulation

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria

October 13, 2020 - 12:48 -- Open Access
Dieng MM, Diawara A, Idaghdour Y, et al.
Nat Commun. 2020 Oct 9;11(1):5093

The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria.

Not Open Access | The second life of Plasmodium in the mosquito host: gene regulation on the move

November 26, 2019 - 18:16 -- NOT Open Access
José L Ruiz, Elena Gómez-Díaz
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 313–357

Malaria parasites face dynamically changing environments and strong selective constraints within human and mosquito hosts. To survive such hostile and shifting conditions, Plasmodium switches transcriptional programs during development and has evolved mechanisms to adjust its phenotype through heterogeneous patterns of gene expression. In vitro studies on culture-adapted isolates have served to set the link between chromatin structure and functional gene expression.

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