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chromatin structure

Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites

January 7, 2021 - 09:06 -- Open Access
Hollin T, Gupta M, Lenz T, Le Roch KG
Trends Genet. 2021 Jan;37(1):73-85

Multiple hosts and various life cycle stages prompt the human malaria parasite, Plasmodium falciparum, to acquire sophisticated molecular mechanisms to ensure its survival, spread, and transmission to its next host. To face these environmental challenges, increasing evidence suggests that the parasite has developed complex and complementary layers of regulatory mechanisms controlling gene expression.

Not Open Access | The role of epigenetics and chromatin structure in transcriptional regulation in malaria parasites

November 26, 2019 - 18:08 -- NOT Open Access
Steven Abel, Karine G Le Roch
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 302–313

Due to the unique selective pressures and extreme changes faced by the human malaria parasite Plasmodium falciparum throughout its life cycle, the parasite has evolved distinct features to alter its gene expression patterns. Along with classical gene regulation by transcription factors (TFs), of which only one family, the AP2 TFs, has been described in the parasite genome, a large body of evidence points toward chromatin structure and epigenetic factors mediating the changes in gene expression associated with parasite life cycle stages.

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