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histidine-rich protein II

Ultrasensitive and label-free biosensor for the detection of Plasmodium falciparum histidine-rich protein II in saliva

November 27, 2019 - 16:18 -- Open Access
Soraya GV, Abeyrathne CD, Buffet C, Huynh DH, Uddin SM, Chan J, Skafidas E, Kwan P, Rogerson SJ
Sci Rep. 2019 Nov 25;9(1):17495

Malaria elimination is a global public health priority. To fulfil the demands of elimination diagnostics, we have developed an interdigitated electrode sensor platform targeting the Plasmodium falciparum Histidine Rich Protein 2 (PfHRP2) protein in saliva samples. A protocol for frequency-specific PfHRP2 detection in phosphate buffered saline was developed, yielding a sensitivity of 2.5 pg/mL based on change in impedance magnitude of the sensor.

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