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adults

NOT Open Access | Treating Severe Malaria

October 1, 2020 - 15:44 -- NOT Open Access
Author(s): 
Berman JD
Reference: 
Clin Infect Dis. 2020 Sep 30:ciaa887

In “Concomitant bacteremia in adults with severe falciparum malaria” in this issue of Clinical Infectious Diseases, 9 of 845 Southeast Asian adults with severe malaria (1%) had bacteremia upon admission, but 4 of those 9 patients (44%) died compared with 108 of 836 (13%) nonbacteremic patients.

Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults

September 15, 2020 - 10:09 -- Open Access
Author(s): 
Healy SA, Murphy SC, Duffy PE, et al.
Reference: 
Clin Infect Dis. 2020 Sep 12;71(6):1481-1490

Chemoprophylaxis vaccination with sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sporozoite (PfSPZ) challenge, but whether blood-stage parasite exposure is required for protection remains unclear. Chloroquine suppresses and clears blood-stage parasitemia, while other antimalarial drugs, such as primaquine, act against liver-stage parasites. Here, we evaluated CVac regimens using primaquine and/or chloroquine as the partner drug to discern whether blood-stage parasite exposure impacts protection against homologous controlled human malaria infection.

Implementation of a malaria sentinel surveillance system in Togo: a pilot study

September 10, 2020 - 08:57 -- Open Access
Author(s): 
Anne Thomas, Tchaa A. Bakai, Tinah Atcha-Oubou, Tchassama Tchadjobo and Nicolas Voirin
Reference: 
Malaria Journal 2020 19:330, 9 September 2020

In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which consists of collecting information in real time and analysing this information for decision-making. The first 20 months of malaria morbidity and mortality trends, and malaria case management in health facilities included in the surveillance were assessed.

Physiological and morphological correlates of blood parasite infection in urban and non-urban house sparrow populations

August 22, 2020 - 14:32 -- Open Access
Author(s): 
Bichet C, Brischoux F, Ribout C, Parenteau C, Meillère A, Angelier F
Reference: 
PLoS One. 2020 Aug 19;15(8):e0237170

In the last decade, house sparrow populations have shown a general decline, especially in cities. Avian malaria has been recently suggested as one of the potential causes of this decline, and its detrimental effects could be exacerbated in urban habitats. It was initially thought that avian malaria parasites would not have large negative effects on wild birds because of their long co-evolution with their hosts.

Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

July 15, 2020 - 14:17 -- Open Access
Author(s): 
Camponovo F, Campo JJ, Penny MA, et al.
Reference: 
Elife. 2020 Jul 14; 9:e53080

Tanzanian adult male volunteers were immunized by direct venous inoculation with radiation-attenuated, aseptic, purified, cryopreserved Plasmodium falciparum (Pf) sporozoites (PfSPZ Vaccine) and protective efficacy assessed by homologous controlled human malaria infection (CHMI). Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf protein microarray covering 91% of the proteome, providing first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans.

Descriptive Acute Respiratory Distress Syndrome (ARDS) in adults with imported severe Plasmodium falciparum malaria: A 10 year-study in a Portuguese tertiary care hospital

July 13, 2020 - 16:25 -- Open Access
Author(s): 
Graça L, Abreu IG, Santos AS, Graça L, Dias PF, Santos ML
Reference: 
PLoS ONE 15(7): e0235437

Acute respiratory distress syndrome (ARDS) is a severe complication of malaria that remains largely unstudied. We aim to describe the development of ARDS associated with severe P. falciparum malaria, its management and impact on clinical outcome.

Malaria infection, disease and mortality among children and adults on the coast of Kenya

June 22, 2020 - 16:34 -- Open Access
Author(s): 
Alice Kamau, Grace Mtanje, Robert W. Snow, et al.
Reference: 
Malaria Journal 2020 19:210, 17 June 2020

Malaria transmission has recently fallen in many parts of Africa, but systematic descriptions of infection and disease across all age groups are rare. Here, an epidemiological investigation of parasite prevalence, the incidence of fevers associated with infection, severe hospitalized disease and mortality among children older than 6 months and adults on the Kenyan coast is presented.

Bacteremia in adults with severe malaria

June 8, 2020 - 15:45 -- Open Access
Author(s): 
White NJ
Reference: 
Clin Infect Dis. 2020 Jun 7:ciaa733

Symptomatic malaria is predominantly a disease of childhood in areas of higher transmission (i.e. much of sub-Saharan Africa). Most cases of severe malaria occur in children less than 5 years of age. In these regions both malaria and sepsis are major causes of childhood death, yet the clinical distinction between the two is difficult, particularly if there is no obvious focus of infection. Furthermore, severe malaria predisposes to bacterial infections, particularly with Salmonella sp, so a very sick child  may have both.

NOT Open Access | Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults

May 13, 2020 - 13:57 -- NOT Open Access
Author(s): 
Nouatin O, Ateba Ngoa U, Adegnika AA, et al.
Reference: 
Vaccine. 2020 May 5. pii: S0264-410X(20)30540-5

Despite appreciable immunogenicity in malaria-naive populations, many candidate malaria vaccines are considerably less immunogenic in malaria-exposed populations. This could reflect induction of immune regulatory mechanisms involving Human Leukocyte Antigen G (HLA-G), regulatory T (Treg), and regulatory B (Breg) cells. Here, we addressed the question whether there is correlation between these immune regulatory pathways and both plasmablast frequencies and vaccine-specific IgG concentrations.

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