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Community knowledge, attitudes and practices towards malaria in Ha-Lambani, Limpopo Province, South Africa: a cross-sectional household survey

April 21, 2021 - 14:40 -- Open Access
Mukhethwa Munzhedzi, Elizabeth T. Rogawski McQuade, Jennifer L. Guler, Piper E. Shifflett, Sara Krivacsy, Rebecca Dillingham and Pascal O. Bessong
Malaria Journal 2021 20:188, 17 April 2021

Malaria remains a global health concern and is endemic in Limpopo, Mpumalanga and KwaZulu Natal Provinces of South Africa, which aims to eliminate malaria by 2025. Community engagement plays a significant role in improving the acceptability and effectiveness of programmes aimed at reducing malaria transmission. The success of such intervention efforts depends on the knowledge, attitudes and practices (KAP) of the community, and understanding the KAP of community residents may support malaria control efforts in the locality. In this context, a cross-sectional household survey to assess community KAP on malaria transmission and prevention in the Ha-Lambani village, Vhembe District, Limpopo Province was conducted.

Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses

April 20, 2021 - 15:35 -- Open Access
Remarque EJ, Faber BW, Rodriguez Garcia R, Oostermeijer H, Sirima SB, Nebie Ouedraogo I, Kara L, Launay O, Houard S, Leroy O, Kocken CHM
NPJ Vaccines. 2021 Apr 14;6(1):55

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1's polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversity Covering (DiCo) protein sequences were designed and tested in a staggered phase Ia/b trial.

Epidemiology of Malaria in East Nusa Tenggara Province in Indonesia: Protocol for a Cross-sectional Study

April 14, 2021 - 08:12 -- Open Access
Guntur RD, Kingsley J, Islam FMA
JMIR Res Protoc. 2021 Apr 9;10(4):e23545

Malaria is a global pandemic that results in approximately 228 million cases globally; 3.5% of these cases are in Southeast Asian countries, including Indonesia. Following the World Health Organization (WHO) initiative, Indonesia is in the process of achieving malaria-free zone status by 2030. However, the eastern part of Indonesia, including the East Nusa Tenggara Province (ENTP), still has a disproportionately high rate of malaria.

Are malaria transmission-blocking vaccines acceptable to high burden communities? Results from a mixed methods study in Bo, Sierra Leone

April 14, 2021 - 08:11 -- Open Access
Kaci D. McCoy, Caroline T. Weldon, Rashid Ansumana, Joseph M. Lamin, David A. Stenger, Sadie J. Ryan, Kevin Bardosh, Kathryn H. Jacobsen and Rhoel R. Dinglasan
Malaria Journal 2021 20:183, 13 April 2021

Malaria transmission-blocking vaccines (TBVs) could help break the cycle of malaria transmission by conferring community rather than individual protection. When introducing new intervention strategies, uptake is dependent on acceptability, not just efficacy. In this exploratory study on acceptability of TBVs in Sierra Leone, it was hypothesized that TBVs would be largely acceptable to adults and health workers in areas with relatively few ongoing malaria interventions, and that (i) knowledge of malaria and vaccines, (ii) health behaviours associated with malaria and vaccines, and (iii) attitudes towards different vaccines types could lead to greater TBV acceptability.

Mechanisms and targets of Fcgamma-receptor mediated immunity to malaria sporozoites

March 23, 2021 - 14:49 -- Open Access
Feng G, Wines BD, Beeson JG, et al.
Nat Commun. 2021 Mar 19;12(1):1742

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is crucial for developing vaccines with high efficacy. Here, we identify key roles in humoral immunity for Fcγ-receptor (FcγR) interactions and opsonic phagocytosis of sporozoites. We identify a major role for neutrophils in mediating phagocytic clearance of sporozoites in peripheral blood, whereas monocytes contribute a minor role.

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

March 23, 2021 - 14:35 -- Open Access
Coelho CH, Tang WK, Duffy PE, et al.
Nat Commun. 2021 Mar 19;12(1):1750

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum parasites.

NOT Open Access | Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults

January 5, 2021 - 15:38 -- NOT Open Access
Jongo SA, Church LWP, Hoffman SL, et al.
Clin Infect Dis. 2020 Dec 31;71(11):2849-2857

A vaccine would be an ideal tool for reducing malaria’s impact. PfSPZ Vaccine (radiation attenuated, aseptic, purified, cryopreserved Plasmodium falciparum [Pf] sporozoites [SPZ]) has been well tolerated and safe in >1526 malaria-naive and experienced 6-month to 65-year-olds in the United States, Europe, and Africa. When vaccine efficacy (VE) of 5 doses of 2.7 × 105 PfSPZ of PfSPZ Vaccine was assessed in adults against controlled human malaria infection (CHMI) in the United States and Tanzania and intense field transmission of heterogeneous Pf in Mali, Tanzanians had the lowest VE (20%).

NOT Open Access | Adults Are Not Big Children: What Brain Magnetic Resonance Imaging Findings Tell Us About Differences in Pediatric and Adult Cerebral Malaria

December 16, 2020 - 10:51 -- NOT Open Access
John CC
Clin Infect Dis. 2020 Dec 16:ciaa1659

Historically, research studies of infections in children have lagged behind those in adults. There are many reasons for this, including the smaller population of children, resulting in smaller numbers for research studies; a reluctance to subject children to the procedures required and the potential harms from new interventions; and a lack of financial incentive with the smaller market for drugs for pediatric conditions.

Concomitant Bacteremia in Adults With Severe Falciparum Malaria

December 8, 2020 - 11:25 -- Open Access
Phu NH, Day NPJ, Tuan PQ, Mai NTH, Chau TTH, Van Chuong L, Vinh H, Loc PP, Sinh DX, Hoa NTT, Waller DJ, Wain J, Jeyapant A, Watson JA, Farrar JJ, Hien TT, Parry CM, White NJ
Clin Infect Dis. 2020 Dec 3;71(9):e465-e470

Approximately 6% of children hospitalized with severe falciparum malaria in Africa are also bacteremic. It is therefore recommended that all children with severe malaria should receive broad-spectrum antibiotics in addition to parenteral artesunate. Empirical antibiotics are not recommended currently for adults with severe malaria.

Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso

December 3, 2020 - 12:24 -- Open Access
Kaboré B, Post A, Berendsen MLT, Diallo S, Lompo P, Derra K, Rouamba E, Jacobs J, Tinto H, de Mast Q, van der Ven AJ
PLoS One. 2020 Nov 30;15(11):e0242507

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive analysis of RBC hemostasis. Complete blood counts were analysed in subjects from all age groups (n = 1118) living in a malaria hyperendemic area and cytokines and iron biomarkers were also measured. Subjects were divided into age groups (<2 years, 2-4, 5-14 and ≥15 years old) and clinical categories (smear-negative healthy subjects, asymptomatic malaria and clinical malaria).


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