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susceptibility

Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium

February 17, 2020 - 12:10 -- Open Access
Author(s): 
Dieme C, Zmarlak NM, Brito-Fravallo E, Travaillé C, Pain A, Cherrier F, Genève C, Calvo-Alvarez E, Riehle MM, Vernick KD, Rotureau B, Mitri C
Reference: 
PLoS Negl Trop Dis 14(2): e0008059

During a blood meal, female Anopheles mosquitoes are potentially exposed to diverse microbes in addition to the malaria parasite, Plasmodium. Human and animal African trypanosomiases are frequently co-endemic with malaria in Africa. It is not known whether exposure of Anopheles to trypanosomes influences their fitness or ability to transmit Plasmodium. Using cell and molecular biology approaches, we found that Trypanosoma brucei brucei parasites survive for at least 48h after infectious blood meal in the midgut of the major malaria vector, Anopheles coluzzii before being cleared.

NOT Open Access | Atovaquone/proguanil for malaria chemoprophylaxis - Could a difference in susceptibility during hepatic development explain the need to continue drug intake for 7 days post-exposure?

November 26, 2019 - 13:36 -- NOT Open Access
Author(s): 
Hanscheid T, Schlagenhauf P, Grobusch MP.
Reference: 
Travel Medicine and Infectious Disease, 21 November 2019, 101527

No abstract available

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