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age-dependency

A threshold-free approach with age-dependency for estimating malaria seroprevalence

January 12, 2022 - 23:36 -- Open Access
Author(s): 
Irene Kyomuhangi and Emanuele Giorgi
Reference: 
Malaria Journal 2022 21:1, 3 January 2022

In malaria serology analysis, the standard approach to obtain seroprevalence, i.e the proportion of seropositive individuals in a population, is based on a threshold which is used to classify individuals as seropositive or seronegative. The choice of this threshold is often arbitrary and is based on methods that ignore the age-dependency of the antibody distribution.

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