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epidemiology; genotyping; hypnozoite; identity by descent; malaria; meiotic sibling; Plasmodium vivax; primaquine; relapse; single-cell sequencing; tafenoquine; whole-genome sequencing

Homologous P. vivax malarial recurrences are not necessarily relapses

November 26, 2021 - 10:29 -- Miles Markus

It was pointed out a decade ago that non-reinfection recurrences of Plasmodium vivax malaria caused by parasites that are closely related to those from an earlier time point are highly suggestive of a merozoite origin [1,2].

This would make them recrudescences (in an unknown proportion of cases), not relapses. In other words, hypnozoites [3] have nothing to do with such a recurrence.

Some recurrences that take place after 28 days post infection are also recrudescences (not relapses), as has recently been explained [2].

 

 

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