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Immunogenicity of full-length P. vivax rPvs48/45 protein formulations in BALB/c mice

November 25, 2021 - 13:04 -- Open Access
Author(s): 
Arévalo-Herrera M, Miura K, Solano E, Sebastián Ramírez J, Long CA, Corradin G, Herrera S
Reference: 
Vaccine. 2021 Nov 18:S0264-410X(21)01481-X

Pvs48/45 is a Plasmodium vivax gametocyte surface protein involved in the parasite fertilization process. Previous studies showed that Pvs48/45 proteins expressed in Escherichia coli (E. coli) and Chinese hamster ovary (CHO) cells were highly immunoreactive with sera from malaria-endemic areas and highly immunogenic in animal models. Here the immunogenicity in mice of three different vaccine formulations was compared.

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