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g-quadruplex RNA

G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum

November 25, 2021 - 12:48 -- Open Access
Dumetz F, Chow EY, Harris LM, Liew SW, Jensen A, Umar MI, Chung B, Chan TF, Merrick CJ, Kwok CK
Nucleic Acids Res. 2021 Nov 18:gkab1095

G-quadruplexes are non-helical secondary structures that can fold in vivo in both DNA and RNA. In human cells, they can influence replication, transcription and telomere maintenance in DNA, or translation, transcript processing and stability of RNA. We have previously showed that G-quadruplexes are detectable in the DNA of the malaria parasite Plasmodium falciparum, despite a very highly A/T-biased genome with unusually few guanine-rich sequences. Here, we show that RNA G-quadruplexes can also form in P. falciparum RNA, using rG4-seq for transcriptome-wide structure-specific RNA probing.

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