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Not Open Access | Adherence and population pharmacokinetic properties of amodiaquine when used for seasonal malaria chemoprevention in African children

November 19, 2019 - 14:56 -- NOT Open Access
Junjie Ding, Matthew E. Coldiron, Joel Tarning, et al.
Clinical Pharmacology & Therapeutics, Volume 106, Issue 6

The developed methodology to evaluate adherence showed a sensitivity of 65‐71% when the first dose of SMC was directly observed and 71‐73% when no doses were observed in a routine programmatic setting. Adherence simulations and measured desethylamodiaquine concentrations in the case‐control children showed complete adherence (all doses taken) in less than 20% of children. 

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