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123-triazole derivatives

NOT Open Access | 1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity

October 12, 2021 - 10:26 -- NOT Open Access
Valério Lopes F, Fazza Stroppa PH, Marinho JA, Reis Soares R, Alves Azevedo L, Capriles Goliatt PVZ, Abramo C, David da Silva A
Chem Biol Interact. 2021 Oct 7:109688

Malaria remains one of the most important parasitic diseases in the world. The multidrug-resistant Plasmodium strains make the treatment currently available for malaria less effective. Therefore, the development of new drugs is necessary to overcome therapy resistance. Triazole derivatives exhibit several biological activities and provide a moiety that is promising from the biological perspective. Due to the structural similarity to NADH, it is believed that triazoles can bind to the active site of the Plasmodium lactate dehydrogenase (pLDH) enzyme.

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