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antibody signatures

Antibody signatures of asymptomatic Plasmodium falciparum malaria infections measured from dried blood spots

October 6, 2021 - 20:12 -- Open Access
Christine F. Markwalter, Myat Htut Nyunt, Zay Yar Han, Ricardo Henao, Aarti Jain, Omid Taghavian, Philip L. Felgner, Kay Thwe Han, Myaing M. Nyunt and Christopher V. Plowe
Malaria Journal 2021 20:378, 23 September 2021

Screening malaria-specific antibody responses on protein microarrays can help identify immune factors that mediate protection against malaria infection, disease, and transmission, as well as markers of past exposure to both malaria parasites and mosquito vectors. Most malaria protein microarray work has used serum as the sample matrix, requiring prompt laboratory processing and a continuous cold chain, thus limiting applications in remote locations. Dried blood spots (DBS) pose minimal biohazard, do not require immediate laboratory processing, and are stable at room temperature for transport, making them potentially superior alternatives to serum. The goals of this study were to assess the viability of DBS as a source for antibody profiling and to use DBS to identify serological signatures of low-density Plasmodium falciparum infections in malaria-endemic regions of Myanmar.

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