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redox-mediated phenomenon

Resistance to artemisinin in falciparum malaria parasites: A redox-mediated phenomenon

August 25, 2021 - 16:10 -- Open Access
Author(s): 
Egwu CO, Pério P, Augereau JM, Tsamesidis I, Benoit-Vical F, Reybier K
Reference: 
Free Radic Biol Med. 2021 Aug 17:S0891-5849(21)00476-7

Malaria remains a major public health disease due to its high yearly mortality and morbidity. Resistance to the gold standard drug, artemisinin, is worrisome and needs better understanding in order to be overcome. In this work, we sought to study whether redox processes are involved in artemisinin resistance. As artemisinin is known to act among others via production of reactive species, we first compared the production of reactive oxygen species and concomitant protein oxidation in artemisinin-sensitive and artemisinin-resistant parasites when treated with artemisinin.

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